CACNA1A

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CACNA1A

A gene on chromosome 19p13 that encodes the alpha-1A subunit of a voltage-dependent P/Q-type calcium channel, which mediates the entry of calcium ions into excitable cells. These channels are also involved in various calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and apoptosis.

Molecular pathology
CACNA1A mutations are associated with familial hemiplegic migraine and episodic ataxia 2.
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MDA-MB-231 cells were pretreated with 10 [micro]M MHP1 for 24 h, and then injected into the tail vein of nude mice.
A potential interpretation is that the effect of MHP1 on cancer cell proliferation depends on its effect on mitogenic factors; however, 10 [micro]M MHP-1 did not significantly affect the secretion of these factors, including PDGF, VEGF, bFGF and HGF, as evidenced in Fig.
MHP1 a Magnaporthe grisea Hydrophobin gene is required for fungal development and plant colonization.
The graded MHP of 0.5%, 1.0%, 1.5%, and 2.0%, and 2.0% MCP as a positive control were incorporated to diet without P source (control) in lieu of cellulose and the diets were designated as MHP0.5, MHP1.0, MHP1.5, MHP2.0, and MCP, respectively.
Fish group fed MHP2.0 showed the highest WG of 446.7%, which was not significantly different (p>0.05) from those of fish groups MHP1.0, MHP1.5, and MCP, while fish groups fed control and MHP0.5 showed lower WG than the other groups (p<0.05).
However, the ALT (IU/L) did not show such a relevant trend and ranged from 6.2 (MHP1.5 and MCP) to 8.0 (MHP0.5), which was not significantly different among fish groups.
However, fish fed above 0.57% AP (MHP1.0) showed a significantly improved WG, FE, PER, and SGR with a peak at 0.73% AP.
Characterization of the gene encoding Mhp1 from Mycoplasma hyopneumoniae and examination of Mhp1's vaccine potential.