MHC restriction


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MHC re·stric·tion

T helper cells only recognize an antigen that is presented with class II major histocompatibility antigens whereas T cytotoxic cells usually only recognize a processed antigen in conjunction with class I major histocompatibility antigens.
Farlex Partner Medical Dictionary © Farlex 2012

MHC restriction

The ability of T cells to recognise antigens when associated with the organism’s own MHC haplotype, providing a dual recognition system critical to T-cell function. (See Antigen-presenting cell, MHC.)

MHCR occurs in the thymus before a T cell becomes a functional antigen-specific cell in the peripheral immune system; the selection process operates on the α/β heterodimer of the T-cell receptor, assuring that the T cells will react with the product of the MHC, and not with self-antigens (i.e., the process is “self-tolerant”).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

MHC restriction

Immunology The ability of T cells to recognize antigens when associated with the organism's own MHC haplotype, providing a dual recognition system critical to T-cell function. See Antigen-presenting cell, MHC.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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MHC restriction is an important parameter related to T cell assays, as well as MHC binding and ligand elution assays.
The home page interface contains six sections or panes that allow users to search by major categories of epitope, antigen, host, assay, MHC restriction, and disease.
The MHC Restriction pane enables queries for the restrictions captured for a given epitope in a given T cell, MHC binding, or elution assay.
The columns indicate the reference, epitope, host, immunization process, the assayed antigen, its relationship to the epitope, the MHC restriction (if defined and recorded), the assay type, and the qualitative value (positive or negative).
Cytotoxic cells can be classified based on antigen specificity and MHC restriction, i.e., nonspecific cytotoxic cells and antigen-specific, MHC-restricted CTLs.