References in periodicals archive ?
A major complication for predicting T-cell epitopes through peptide-MHC binding models is MHC polymorphism. In humans, MHC molecules are known as human leukocyte antigens (HLAs), and there are hundreds of allelic variants of class I (HLA I) and class II (HLA II) molecules.
MHC polymorphism and disease resistance in Atlantic salmon (Salmosalar); facing pathogens with single expressed major histocompatibility class I and class II loci.
With the development of study, growing eidence showed that high degrees of MHC polymorphism are closely related to resistance or susceptibility to disease in mammals (Medina et al., 1998; Paterson et al., 1998;Hill et al.,1991;Tang et al., 2012), poultry (Briles et al., 1983; Nikolich-Zugich et al., 2004; Banat et al., 2012) and teleost fish (Zhang et al., 2006b; Wynne et al., 2007; Rakus et al., 2009; Du et al., 2011).
However, only one MHC class II B locus was identified in Chinese long snout catfish (Shen et al., 2011).In mammals, MHC polymorphism is maintained over long times by positive (balancing) selection at the nonsynonymous sites specifying the PBR of the MHC molecule (Graser et al., 1996).
Maintenance of MHC polymorphism. Nature 1992; 355: 402-3.
Trans-specific MHC polymorphism and the origin of species in primates J.
MHC polymorphism and disease resistance to vibrio anguillarum in 8 families of half-smooth tongue sole (Cynoglossus semilaevis).
Parasites and sexual selection have been documented to sustain the unusually high levels of MHC polymorphism (Piertney and Oliver, 2006).
MHC polymorphisms can lead to population adaptations to endemic pathogenic micro-organisms if there are limited genetic exchanges or barriers to spatial communication between the populations.
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- MHC Class I Chain Related A
- MHC class II deficiency
- MHC class II regulatory factor RFX
- MHC class III HLA-RP1
- MHC class-II regulatory factor RFX1
- MHC I
- MHC II
- MHC molecule
- MHC polymorphism
- MHC restriction