EPCAM

(redirected from MH99)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
subfastigiatus-Complex mh126, mh129 and mh99 within C1 and designed as Haplotype I, separated from other 4 isolates of this complex mh277, mh295 and mh278 within C2 and designed as Haplotype I.
subfastigiatus were grouped into 2 haplotypes; haplotype I comprised 3 isolates viz., mh126, mh129 and mh99 within C1 clade and haplotype II formed by 4 isolates viz., mh277, mh295 and mh278 within C2 clade (Fig.