2] Nonstandard abbreviations:
MGUS, monoclonal gammopathies of undetermined significance; SPE, serum protein electrophoresis; CZE, capillary zone electrophoresis; IFE, Immunofixation electrophoresis; FLCR, free light chain ratio; MS, mass spectrometry; TOF, time of flight; ESI, electrospray ionization.
Disease entity M-protein
MGUS <30 g/L Smoldering Myeloma >30 g/L in serum Or >1 g/24hour in the urine Symptomatic Myeloma Any value Solitary Plasmacytoma All of the following: Biopsy proven solitary lesion No clonal plasma cells in the bone marrow An otherwise normal skeletal survey and MRI of the spine and pelvis No end organ damage Disease entity Clonal PCs in BM
MGUS <10% Smoldering Myeloma >10% Symptomatic Myeloma >10% <10% if other criteria are met Solitary Plasmacytoma Disease entity End-organ Others damage (CRAB *)
MGUS No No other B-cell lymphoproliferative disorder Smoldering Myeloma No Symptomatic Myeloma Yes Solitary Plasmacytoma * CRAB: Hyper-Calcemia serum calcium >2.
Most
MGUs do have written underwriting guidelines but those guidelines are just for underwriting, not for pricing.
The blood of the participants, aged 30-94, was assessed for
MGUS prevalence.
Mobile device use has grown among carriers and
MGUs, with respondents preferring to use tablets over smartphones for uses other than phone calls: 62 percent of respondents prefer to use tablets for tasks other than phone calls, compared to 21 percent for smartphones.
I don't think you can adequately manage
MGU relationships without a good team approach; there's just too much complexity, too many moving parts," Dresner said.
It was during an annual blood check that the myeloma, which in a very small number of cases can develop from
MGUS, was first detected.
On the other hand, 16% of IFE-only
MGUS were not found on subsequent testing and had no known intervention to explain the loss of the M-protein (20).
The firms Lloyds syndicate, ANV 1861 proceeds to offer the majority share of the capacity under the
MGUs Lloyds binding authority.
2 yrs) Prasad et al, (10) 1998 Lymphoplasmacytic NA lymphoma Sun et al, (11) 2003 MALT lymphoma NED (9 months) Papla et al, (4) 2004 Multiple myeloma Dead (postoperative) lonescu et None (rheumatoid NA al, (14) 2005 arthritis) Fairweather MALT lymphoma NED (4 months) et al, (12) 2006 Lee et al, (15) 2009 None (treated NA tuberculosis) Todd et al, (16) 2010
MGUS Stable nodule (2 years) Ko et al, (17) 2012 MALT lymphoma NA Abbreviations: LP-PCD, lymphoproliferative/plasma cell disorder; MALT, mucosa-associated lymphoid tissue;
MGUS, monoclonal gammopathy of undetermined significance; NA, not available; NED, no evidence of disease.
