A landmark study led by investigators at the Mayo Clinic demonstrated that the risk of progression of MGUS
to multiple myeloma or a related disorder is independently predicted by three key factors: a high serum
Monoclonal gammopathy of undetermined significance (MGUS
) is a plasma cell disorder,that occurs in 3% of the population aged more than 50 years, and is the commonest among plasma cell dyscrasias.1,2 The hallmark of Monoclonal gammopathies is the expansion of a single clone of plasma cells, which yields a homogeneous monoclonal protein (M-protein/M-component or paraprotein).
Etiologies of NB Myopathy NB in other neuromuscular disorders AD: NEB, ACTA1, TPM3, TPM2 Myopathy Idiopathic inflammatory myopathies Acute alcoholic myopathy AR: ACTA1, TPM3, TPM2, TNNT1, Myotonic dystrophy CFL2, KBTBD13, KLHL40, Sarcoglycanopathies KLHL41, LMOD3, MYPN, MYO18B Mitochondrial myopathy GYG1 polyglucosan body myopathy Late-onset Pompe disease Acquired Neuropathy MGUS
Spinal muscular atrophy HIV-associated myopathy Amyotrophic lateral sclerosis Charcot-Marie-Tooth disease Other Hypothyroidism Chronic renal failure Keys: genes are written in italic font; AD, autosomal dominant; AR, autosomal recessive; NB, nemaline body; MGUS
, monoclonal gammopathy of undetermined significance.
Using the reported prevalence of MGUS
(1%-3% in persons aged [greater than or equal to] 50 years) (2), five MGUS
cases also did not appear unusual.
A study done in the University of Arkansas for Medical Science (UAMS), using plasma cells (PCs) from 74 newly diagnosed myeloma patients, 5 with monoclonal gammopathy of undetermined significance (MGUS
), and 31 healthy volunteers (normal PCs), identified 4 distinct subgroups of MM (MM1, MM2, MM3, and MM4), ranging from MM1 that is more like normal PCs and MGUS
, whereas MM4 showed more poor prognostic features as abnormal karyotype and high serum b2-microglobulin levels .
Vidriales et al., "The progression from MGUS
to smoldering myeloma and eventually to multiple myeloma involves a clonal expansion of genetically abnormal plasma cells," Clinical Cancer Research, vol.
Some studies established that the incidence of cobalamin deficiency in patients with IgA multiple myeloma and MGUS
is approximately 13.6% .
reported 2 cases of donor origin PTLD who developed monoclonal gammopathy of undetermined significance (MGUS
) in a 28-year-old female and an 18-year-old male patient who underwent heart-lung transplantation due to primary pulmonary hypertension .
Hutchison et al., "Monoclonal gammopathy of renal significance: when MGUS
is no longer undetermined or insignificant," Blood,vol.
Increasingly referred to as CHIP, this novel preleukemic condition is seen to differ diagnostically from other preleukemic conditions such as monoclonal gammopathy of unknown significance (MGUS
) and monoclonal B-cell lymphocytosis (MBL) [28, 98].
But we now know that low-concentration monoclonal gammopathies of undetermined significance (MGUS
)  represent disorders that will, in a significant percentage of cases, eventually become malignant diseases (1).
Hoping to tackle the Birmingham Bikeathon for the first time is Bromsgrove resident Toby Gosnall, who was diagnosed with MGUS
- a precursor condition to blood cancer myeloma - in late 2013.