ALDH3A1(redirected from MGC10406)
ALDH3A1A gene on chromosome 17p11.2 that encodes an aldehyde dehydrogenase that plays a major role in detoxifying alcohol-derived acetaldehyde, metabolising corticosteroids, biogenic amines, neurotransmitters and in lipid peroxidation. The ALDH3A1 gene product forms a homodimer that preferentially oxidises aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It appears to promote resistance to UV light-induced oxidative damage in the cornea.
ALDH3A1 mutation may cause Smith-Magenis syndrome.
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