TRAF2(redirected from MGC:450122)
TRAF2A gene on chromosome 9q34 that encodes TNF receptor-associated factor 2, an adapter molecule which regulates NF-kappaB and JNK activation and plays a role in regulating cell survival and apoptosis. TRAF2 is required for normal antibody isotype switching from IgM to IgG. It has E3 ubiquitin-protein ligase activity and promotes Lys-63-linked ubiquitination of target proteins (e.g., BIRC3, RIPK1 and TICAM1).
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