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A gene on chromosome 20p13 that encodes a ubiquitous immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, and may play a key role in intracellular signalling during synaptogenesis and in synaptic function. It downregulates receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors and insulin; it also downregulates phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. It is highly expressed in the brain.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


1. A document that, if signed by the patient or the patient's legal representative, permits the treating health care provider to perform certain procedures. In addition to being signed by the patient, the release should also be signed by a witness. Most releases have a notation indicating the applicable time of the release.
2. To discharge.
3. To remove restraints.

extended release

In pharmacology, the slow or gradual absorption of a drug after ingestion, e.g., one that achieves a peak concentration in the blood after about 6 hr.

immediate release

In pharmacology, the rapid absorption of a drug after ingestion.

myofascial release

Abbreviation: MFR
The manipulation of soft tissue to facilitate improved posture and range of motion and to decrease pain.
See: soft-tissue mobilization

surgical release

Freeing tissues or organs trapped in place by adhesions or scars.

sustained release

The delivery of a drug from a tablet or other reservoir over many hours or days (instead of minutes or hours), to provide a durable therapeutic effect.

myofascial release

Abbreviation: MFR
The manipulation of soft tissue to facilitate improved posture and range of motion and to decrease pain.
See: soft-tissue mobilization
See also: release
Medical Dictionary, © 2009 Farlex and Partners
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References in periodicals archive ?
However, between about 30 ppm and 200 ppm moisture content, the MFR of these materials tends to be essentially constant.
The greater storage volume of the 60 gallon (227 L) Mfr A model has higher overall FHRs than the 50 gallon (189 L) Mfr B and Mfr C units.
For the 2000 grading process, researchers at the Maxwell School developed and used quantitative scales for each of the MFR criteria and subcriteria and based on closed-ended responses to survey questions and content analysis of public documents (see appendix).
The equipment at the first site can connect to the network over a T-3 frame relay service, while the connection at the other site may be carried over a group of T-1 lines running FRF.16-based MFR.
Ideally, we would not perform MFR tests on filled materials; we would instead employ solution-based measurements that work by dissolving the polymer in a solvent and removing the filler so that only the polymer is being considered.
The MFR has already been the subject of a separate Government review by the Department of Social Services which was released in September.
Small changes in the MFR of the polymer during the molding process are to be expected.
'The crude calculation method used to work out the MFR has not stood up to the sophisticated nature of investment markets.
1-year ranking: MFR 1-Star (Previous -June 30, 2014: MFR 3-Star) 3-year wt.avg.
The MFR values suggest a larger difference than the viscosity measurements indicate because the shear rate for the two MFR tests is not the same.
'The Government doesn't have to tell us when the review is coming out but could say it won't be until Parliament returns,' said Mr Barr, who has set up a website about the MFR:
The MFR instruments come with a go/no-go gauge for the orifice diameter that must be used regularly to ensure that the opening is within specification.