MFGE8

MFGE8

A gene on chromosome 15q25 that encodes medin (milk fat globule-EGF factor 8 protein), which plays a key role in maintaining epithelial homeostasis and in promoting mucosal healing. Medin promotes VEGF-dependent neovascularisation, helps remove apoptotosed cells, binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner and binds rotavirus, inhibiting its replication.
References in periodicals archive ?
The third way is to fuse the exogenous proteins with lipid-binding C1C2 domains of the human lactadherin protein (MFGE8) noncovalently [85, 87, 88] (Figure 2(a)).
(a) Three ways to create bioengineered exosomes: (1) Transfect exogenous antitumor antigen into exosomes directly; (2) bind the antitumor antigen onto exosome membrane surface protein LAMP-2b; (3) fuse antitumor antigen with lipid-binding C1C2 domains of the human lactadherin protein MFGE8 noncovalently.
Uptake of these components is mediated by different mannose receptors [27] and by glycoprotein milk fat globule epidermal growth factor 8 (Mfge8) [219].