MERLIN-TIMI 36 | definition of MERLIN-TIMI 36 by Medical dictionary
MERLIN (redirected from MERLIN-TIMI 36)
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A tumor suppressor protein encoded by the neurofibromatosis type 2 gene and important in the pathogenesis of neurofibromatosis type 2.(1) Merlin. A cytoskeleton scaffolding protein [OMIM 607379] which links actin filaments to cell membrane glycoproteins. It is primarily located in nervous tissue, but is also present in foetal tissues at adherens junctions.
(2) MERLIN-TIMI 36. Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndromes. A trial that evaluated the efficacy and safety of long-term ranolazine in patients with non-ST-elevation acute coronary syndromes who were receiving standard therapy
Conclusion The only parameter to reach statistical significance was recurrent ischaemia, which was lower in ranolazine—14%—than in placebo patients—16%; p = 0.03. There were no difference in total mortality with ranolazine vs. placebo; p = 0.91
(3) MERLIN. Middlesbrough Early Revascularization to Limit Infarction
MERLIN Abbrev. for Medical Emergency Relief International.
References in periodicals archive
The revised label says that in the MERLIN-TIMI 36
study--which compared ranolazine to placebo in more than 6,000 patients with acute coronary syndrome--no benefit was seen on outcome measures, but that "ventricular arrhythmias were less common on ranolazine."
Morrow noted in presenting the MERLIN-TIMI 36
(Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary Syndrome--Thrombolysis in MI) results at the annual meeting of the American College of Cardiology.
The design and primary results of the MERLIN-TIMI 36
trial have been published (12-14).