MEN2B


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MEN2B

RET

A gene on chromosome 10q11.2 that encodes a receptor for tyrosine-protein kinase involved in various cellular processes, including cell proliferation and migration, neuronal navigation and cell differentiation, upon binding with glial-cell-derived neurotrophic factor family ligands. RET regulates cell death/survival, balance and positional information. It orchestrates molecular cascades during intestinal, gut neuroendocrine, gut MALT and renal organogenesis, and it modulates cell adhesion by cleaving caspase in sympathetic neurons and mediates cell migration in an integrin (e.g., ITGB1 and ITGB3)-dependent manner. RET triggers apoptosis by intracellular caspase cleavage; it promotes survival and downregulates growth hormone production, but triggers apoptosis in absence of GDNF.

Molecular pathology
RET mutations are associated with  neuroendocrine cancers, which are characterised by defects in integrin-regulated cell migration.

MEN2B

Abbreviation for multiple endocrine neoplasia 2B.
References in periodicals archive ?
RET proto-oncogene mutations are restricted to codons 634 and 918 in mainland Chinese families with MEN2A and MEN2B. Clin Endocrinol (Oxf) 2007;67:570-576.
Patients with phenotypic features resembling MEN2B always require genetic testing even if the family history is negative, because of the high incidence of spontaneous mutations (approximately 50%) (32,33) and the early onset of MTC.
The high incidence of early aggressive tumours associated with MEN2B (11,34) warrants an aggressive surgical approach with early prophylactic thyroidectomy in gene carriers (<1 year).6,13 Total thyroidectomy is recommended, with central lymph node dissection being added in cases of MEN2B.
And it's not just on the other side of the water that Men2B are gaining a huge following.
"If the gay community like to follow Men2b that's their prerogative.
Men2B will also be one of the bill toppers at the Rose of Tralee Festival later this month and are set for several UK TV appearances to coincide with the release of their single.