MEN1


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MEN1

MEN1

Abbreviation for multiple endocrine neoplasia 1.
References in periodicals archive ?
Sometimes a patient with MEN1 knows of no other case of FMEN1 among relatives.
DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors.
7] Human genes: MEN1, multiple endocrine neoplasia 1; RET, ret protooncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease).
PanNECs (high-grade neuroendocrine carcinomas of small cell or large cell type), on the other hand, are infrequently associated with MEN1 and retain DAXX and ATRX immunoreactivity.
In the case of the MEN1 gene, evidence is beginning to accumulate that suggests that its function is likely to be lost in some sporadic cancers of the same tissues affected in the hereditary MEN1 syndrome.
Type-III ECL-cell NETs occur sporadically in the absence of ECL-cell hyperplasia or dysplasia and are not associated with hypergastrinemia, chronic atrophic gastritis, MEN1, or Zollinger-Ellison syndrome.
Of note, clear cell pancreatic NETs can also occur, although less commonly, in patients with MEN1 syndrome (22); therefore, the finding of a clear cell pancreatic NET should not prompt the pathologist to reflexively suggest the patient be examined for VHL, but should also bring MEN1 to consideration in the differential diagnosis.
The mutated tumor suppressor gene MEN1 encodes a nuclear protein, menin, whose function it is to interact with SMAD3 to suppress transforming growth factor [beta].
7) They arise almost exclusively in the ampulla or periampullary duodenum and are often associated with MEN1 and with neurofibromatosis type 1.
MEN1 gene encodes a 68-kDa protein of 610 amino acids named menin.
Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism.