ORAI2(redirected from MEM142B)
ORAI2A gene on chromosome 7q22.1 that encodes a Ca2+ release-activated Ca2+ (CRAC) channel subunit, which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T cells and promote an immune response to pathogens by activating the transcription factor NFAT.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.