MELD score

MELD score

Model for End-stage Liver Disease score. A system used to prioritise patients on liver transplant waiting lists, which may be less powerful in predicting death or removal from the waiting list due to deteriorating liver function than the Child-Turcotte-Pugh scoring system.

MELD score

[acronym for model end state liver disease]
A tool for characterizing the severity of liver disease, esp. used in patients who are seeking a liver transplant. Patients with higher scores (more severe liver disease) are given a higher priority for receiving donor organs. MELD relies on the repeated measurement of three variables: the total bilirubin level, the serum creatinine level, and the INR (international normalized ratio), as adjusted by the following equation: MELD score = 10[0.957L(serum creatinine) + 0.378Ln(total bilirubin) + 1.12Ln(INR) +0.643.
References in periodicals archive ?
The MELD score and its components improved in survivors especially at day 30 onwards but there were no significant differences across study arms.
A multivariate analysis that adjusted for age, gender, MELD score, and Child-Pugh score found that "impaired contractile response was the strongest predictor of hepatorenal syndrome" as defined by a less than 22% increase in cardiac output following dobutamine.
Child-Turcotte-Pugh versus MELD score as a predictor of outcome after elective and emergent surgery in cirrhotic patients.
The effect of covariates on unadjusted recipient survival for first transplants in patients with non-acute liver failure (ALF) was determined by Cox proportional hazards regression and included recipient age and BMI at transplant, recipient gender, DRI, allograft type, recipient length of hospital stay, operation time, cold ischaemic time, MELD score pre-transplant, health status pre-surgery (diabetes mellitus, ascites), centre experience (era 1 v.
Three risk factors for AKI post-OLT were presented, preoperative calculated MELD score (odds ratio [OR] = 1.048, P = 0.021), intraoperative volume of red cell suspension transfusion (OR = 1.001, P = 0.002), and preoperative liver cirrhosis (OR = 2.015, P = 0.012).
OLD acceptance also correlated with a reduced risk for mortality within the first 90 days for candidates with a MELD score of 35 to 40 (adjusted hazard ratio, 0.22).
Patient characteristics at the time of HCC diagnosis Definitive LRT Wait-and-not-treat P Age (years) 70.4[+ or -]10.2 58.7[+ or -]5.9 <0.001 (*) Female gender 9 (47.4) 12 (21.1) 0.026 (*) Primary diagnosis HCV 12 (63.2) 44 (77.2) 0.420 HBV 0 (0) 2 (3.5) Alcoholic cirrhosis 2 (10.4) 5 (8.8) NASH 3 (15.8) 3 (5.3) Cryptogenic cirrhosis 1 (5.3) 2 (3.5) AIH 1 (5.3) 1 (1.7) Total bilirubin 1.1[+ or -]0.7 1.8[+ or -]1.9 0.120 (mg/dL) MELD score 11.1[+ or -]4.0 11.8[+ or -]4.5 0.550 AFP (ng/mL) 69.9[+ or -]191.8 42.5[+ or -]81.2 0.384 Child-Pugh score 6.2[+ or -]1.4 7.2[+ or -]1.9 0.048 (*) Data are presented as n (%) or mean[+ or -]standard deviation.
Preoperatively, patients were assessed for etiology of liver disease; presence of ascites was assessed using ultrasound and imaging modalities (computed tomography (CT) or magnetic resonance (MRI)); presence of esophageal varices was assessed on endoscopy; a C-P grade was assigned (10); and MELD score was determined (16).
Severity of the liver disease assessed according to Child-Turcotte Pugh score, MELD score and MELD Na score.
Liver function tests (INR, ALT levels, albumin) and MELD score improved or remained unchanged between week 24 and week 72, indicating stabilisation of liver function.
deceased (N=77), we tried to identify possible risk factors for prediction of rebleeding and early mortality by analyzing the following parameters: the degree of hepatic insufficiency (Child-Pugh classification and MELD score, albumin, cholinesterase, bilirubin), the severity of bleeding (anemia, hemorrhagic shock,), endoscopic parameters (variceal grade, active bleeding at endoscopy), coagulation disorders (platelets count and INR), etiology of cirrhosis, decompensation of the underlying disease (vascular, parenchymatous) (Tables 6 and 7).
After adjusting for MELD score, spleen size, and procalcitonin, beta-lactam antibiotics (OR = 1.62,95% CI = 1.64-2.96) and quinolones (OR = 1.53,95% CI = 1.47-2.51) were the only drug classes with a statistically significant association with thrombocytopenia (Table 3).