PCGF2

(redirected from MEL18)

PCGF2

A gene on chromosome 17q12 that encodes a protein that contains a RING finger motif and is similar to the polycomb group (PcG) gene products; it is thought to repress transcription of cytokines, chemokines and chemokine receptors, and thus plays a key role in lymphocyte differentiation and migration, and in immune responses.
References in periodicals archive ?
It is catalysed by RING class heterodimer, chromobox homolog 8 (CBX8), B-Lymphoma moloney murine leukemia virus insertion regional-1 (BMI1), and MEL18 paired with RING1A/B [30, 33].
September 3, 2015 -- Researchers here have discovered a protein, Mel18, that regulates the development of heart muscle.
A protein known as Mel18 is responsible for regulating a piece of cellular machinery that applies temporary silencers to the DNA in developing cells.
BARCELONA, Spain, September 3, 2015 -- Researchers here have discovered a protein, Mel18, that regulates the development of heart muscle.