MAP3K4

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MAP3K4

A gene on chromosome 6q26 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K4 activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway; it specifically phosphorylates and activates MAP2K4 and MAP2K6.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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References in periodicals archive ?
Flavell, "Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development," Proceedings of the National Academy of Sciences of the United States of America, vol.
The MAPKKK in JNK pathway includes MEKK1, MEKK2, MEKK3, and MEKK4, MLK, and ASK1 and MAPKK contain MKK4, MKK3, MKK6, and MKK7 [62, 63].
GADD45[beta]/GADD45[gamma] and MEKK4 comprise a genetic pathway mediating STAT4-independent IFN[gamma] production in T cells.
MAPKK kinases that regulate activation of p38 MAPK include kinases (Mlk1, Mlk2, Mlk3, Dlk, and Lzk), Mekk kinases (Mekk1, Mekk2, Mekk3, and Mekk4), Tak1, Ask1, Ask2, and Tpl- (2.20-26) Activation of the MAPKK kinases or MAPKKs occurs downstream from small G proteins whose function is regulated by the guanine exchange factor proteins.