MAP3K3

(redirected from MEKK3)

MAP3K3

A gene on chromosome 17q23.3 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K3 activates NF-kappaB, AP1 and DDIT3 transcription regulators.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection.
Wang et al., "MEKK3 overexpression contributes to the hyperresponsiveness of IL-12-overproducing cells and CD4+ T conventional cells in nonobese diabetic mice," The Journal of Immunology, vol.
Lin et al., "Differential regulation of interleukin 1 receptor and toll-like receptor signaling by MEKK3," Nature Immunology, vol.
Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-a'-induced c-Jun and NF-B activation and adhesion molecule expression.
Wang et al., "MEKK3 overexpression contributes to the hyperresponsiveness of IL-12-overproducing cells and [CD4.sup.+] T conventional cells in nonobese diabetic mice," The Journal of Immunology, vol.
Huang et al., "Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-a-induced c-Jun and NF-[kappa]B activation and adhesion molecule expression," Circulation Research, vol.
RIP-1 recruitment of MAPK extracellular signal-regulated kinase kinase-3 (MEKK3) and TGF-[beta]-activated kinase (TAK1) activates the I[kappa]B kinase (IKK) complex.
The ubiquitination of IKK[gamma]/NEMO may lead to the recruitment of an I-[kappa]B[beta] kinase, such as MEKK3 or [zeta]PKC to the IKK complex, thereby resulting in I-[kappa]BP phosphorylation and consequently IKK activation.
PA28gamma is an anti-apoptotic factor as it is an endogenous substrate for MEKK3, caspase-3 and caspase-7 (Barton et al.
Huang et al., "Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-[alpha]-induced c-Jun and NF-[kappa]B activation and adhesion molecule expression," Circulation Research, vol.
Guo et al., "The essential role of MEKK3 in TNF-induced NF-[kappa]B activation," Nature Immunology, vol.
The MAPKKK in JNK pathway includes MEKK1, MEKK2, MEKK3, and MEKK4, MLK, and ASK1 and MAPKK contain MKK4, MKK3, MKK6, and MKK7 [62, 63].