MAP3K2

(redirected from MEKK2)

MAP3K2

A gene on chromosome 2q14.3 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K2 regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7, and it plays a role in caveolae kiss-and-run dynamics. MAP3K2 also interacts with MAPK8, SH2D2A, STK38, and XIAP.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2.
The MAPKKK in JNK pathway includes MEKK1, MEKK2, MEKK3, and MEKK4, MLK, and ASK1 and MAPKK contain MKK4, MKK3, MKK6, and MKK7 [62, 63].
Oxidative stress directly or indirectly affects ASK1, MEKK1, MEKK2, MEKK3, MEKK4, and MLK3 and subsequently activates p38 pathway (Figure 3).