MAP3K1

(redirected from MEKK1)

MAP3K1

A gene on chromosome 5q11.2 that encodes a MAPK kinase kinase belonging to the signal transduction cascades. MAP3K1 regulates the ERK and JNK kinase pathways, as well as the NF-kappaB pathway. MAP3K1 is activated by autophosphorylation. 

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.

Molecular
Pathology MAP3K1 defects cause sex reversal type 6.
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References in periodicals archive ?
Statins appear to inhibit PAI-1 promoter activity, through mitogen-activated protein kinase kinase kinase 1 (MEKK1) and, in a lesser extent, NF[kappa]B.
Caption: Figure 3: Detection of host immune response transcription factors including AP-1 binding fos/jun induced by cotransfection of cell cycle inducer MEKK1 and viral ZEBRA switch protein are shown in three EBV positive lymphoblastoid cell lines.
Kyriakis, "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2," Molecular and Cellular Biology, vol.
In Arabidopsis, mitogen-activated protein kinase (MAPK) signaling pathway consisting of MAPK Kinasel (MEKK1), MAPK Kinase2 (MKK2) and MAPK4/6 (MPK4/6) is involved in salt tolerance (Teige et al.
Thus, both IKK and SAPK/ERK kinase 1 (SEK1), an intermediate kinase within the MEKK1 to c-Jun N-terminal kinase (JNK) cascade, are involved in vanadate-induced NF-[kappa]B activation.
Eckert, "Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes," The Journal of Biological Chemistry, vol.
Eight hours after RD cells were infected with EV71, the expression levels of c-Jun, c-Fos, IFN-[beta], MEKK1 (MAP3K1), MLK3 (MAP3K11) and NIK (MAP3K14) revealed 2.08-6.12 fold enhancement, while other 19 genes (e.g.
CDK5 and MEKK1 mediate pro-apoptotic signaling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model.
The cascade consists of upstream regulator proteins (novel protein kinase c and Ras), an MAPK module (MEKK1, MEK3, and p38[delta]) and AP1 transcription factors.
TNF-[alpha] can also activate cellular proliferation through activation of another transcription factor, activator protein-1 (AP-1) [38], which is activated by TNF-[alpha] through sequential recruitment of TNFR1, TRADD, TRAF2, MAP/ERK kinase kinase-1 (MEKK1), MAP kinase kinase-7 (MKK7), and JNK.