MAP3K1

(redirected from MEKK1)

MAP3K1

A gene on chromosome 5q11.2 that encodes a MAPK kinase kinase belonging to the signal transduction cascades. MAP3K1 regulates the ERK and JNK kinase pathways, as well as the NF-kappaB pathway. MAP3K1 is activated by autophosphorylation. 

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.

Molecular
Pathology MAP3K1 defects cause sex reversal type 6.
References in periodicals archive ?
Thus, both IKK and SAPK/ERK kinase 1 (SEK1), an intermediate kinase within the MEKK1 to c-Jun N-terminal kinase (JNK) cascade, are involved in vanadate-induced NF-[kappa]B activation.
Eight hours after RD cells were infected with EV71, the expression levels of c-Jun, c-Fos, IFN-[beta], MEKK1 (MAP3K1), MLK3 (MAP3K11) and NIK (MAP3K14) revealed 2.
CDK5 and MEKK1 mediate pro-apoptotic signaling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model.
MAPK pathways that are activated by MEKK1, TAK1, and ASK1 may link chemical signals to Nrf2 which then leads to the activation of ARE-dependent genes (60).
Whereas NIK preferentially activates IKK[alpha], MEKK1 apparently is more potent in the phosphorylation of IKK[beta] (40).
MEKK1 is a redox-sensitive kinase that could be glutathionylated at C1238 leading to its inactivation [44].
Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes.