MAP3K1

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MAP3K1

A gene on chromosome 5q11.2 that encodes a MAPK kinase kinase belonging to the signal transduction cascades. MAP3K1 regulates the ERK and JNK kinase pathways, as well as the NF-kappaB pathway. MAP3K1 is activated by autophosphorylation. 

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.

Molecular
Pathology MAP3K1 defects cause sex reversal type 6.
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References in periodicals archive ?
This signaling cascade is a linear pathway comprised of calcium-dependent protein kinase (PKC1), a MEKK (BCK1), a pair of redundant MEKs (MKK1/2) and a MAP kinase (MPK1/SLT2) (Figure 1) (2).
mekk 'Geschmack', mekkima 'kosten', pen(n)es 'Eiszapfen am Dache' < est.
JNK(K-R) and MEKK(K-M), the catalytically inactive mutants of, respectively, JNK1 and MEKK in the JNK pathway, attenuate the shear-induced TRE responses.
Ownership: Public (MEKK) Employees: 180 Sales/Emp.: $115,528 Established: 1973 International: 3% 1993 Rank: n/a '92-'93 Growth: 16% 1992: $17,960,000 1987: 1991: $16,210,000 1986: 1990: 1985: 1989: 1984: 1988: 1983:
23r (SUNA)- The Adviser of the Government of the Blue Nile State for the Native Administration, Mekk (Chieftain) Al-Fatih Hussien Adlan, affirmed that a delegation of the Blue Nile State is ready to participate in the coming Addis Ababa 's talks.
MAPKK kinases that regulate activation of p38 MAPK include kinases (Mlk1, Mlk2, Mlk3, Dlk, and Lzk), Mekk kinases (Mekk1, Mekk2, Mekk3, and Mekk4), Tak1, Ask1, Ask2, and Tpl- (2.20-26) Activation of the MAPKK kinases or MAPKKs occurs downstream from small G proteins whose function is regulated by the guanine exchange factor proteins.