MAP3K1

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MAP3K1

A gene on chromosome 5q11.2 that encodes a MAPK kinase kinase belonging to the signal transduction cascades. MAP3K1 regulates the ERK and JNK kinase pathways, as well as the NF-kappaB pathway. MAP3K1 is activated by autophosphorylation. 

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.

Molecular
Pathology MAP3K1 defects cause sex reversal type 6.
References in periodicals archive ?
This signaling cascade is a linear pathway comprised of calcium-dependent protein kinase (PKC1), a MEKK (BCK1), a pair of redundant MEKs (MKK1/2) and a MAP kinase (MPK1/SLT2) (Figure 1) (2).
JNK(K-R) and MEKK(K-M), the catalytically inactive mutants of, respectively, JNK1 and MEKK in the JNK pathway, attenuate the shear-induced TRE responses.