MAP2K3(redirected from MEK3)
MAP2K3A gene on chromosome 17q11.2 that encodes a MAPK kinase belonging to a protein kinase signal transduction cascade. MAP2K3 is a dual-specificity kinase, which is activated by cytokines and environmental stress; it catalyses phosphorylation of threonine and tyrosine residues in MAPK14/MAP kinase p38.
Defects in MAP2K3 have been described in colorectal cancer.
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