MAP2K3

(redirected from MEK3)

MAP2K3

A gene on chromosome 17q11.2 that encodes a MAPK kinase belonging to a protein kinase signal transduction cascade. MAP2K3 is a dual-specificity kinase, which is activated by cytokines and environmental stress; it catalyses phosphorylation of threonine and tyrosine residues in MAPK14/MAP kinase p38.

Molecular pathology
Defects in MAP2K3 have been described in colorectal cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
Eckert, "Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes," The Journal of Biological Chemistry, vol.
The cascade consists of upstream regulator proteins (novel protein kinase c and Ras), an MAPK module (MEKK1, MEK3, and p38[delta]) and AP1 transcription factors.
Thus, a PKC, Ras, MEKK1, MEK3 pathway activates p38[delta] MAPK and p38[delta], in turn, acts to increase binding of selected AP1, Sp1, and C/EBP factors to the hINV promoter to increase promoter activity.
2007) and phosphorylation of p38 MAPK induced the activation of Runx2 via TAK1 and MEK3 signal pathway during early osteoblastic differentiation (Greenblatt et al.