(#ALR-138N) was purchased from AccuStandard Inc., PPAR[gamma] agonist (GW1929, #ab142213) and antagonist (GW9662, #ab141125) from Abcam, and dimethyl sulfoxide (DMSO, #D2650) from Sigma-Aldrich.
The LOD of MMP, MEP, MBP, MBzP, MEHHP, MEOHP, and MEHP
was 0.1 ng/mL, and the detection rates were 72.2%, 99.1%, 99.5%, 100%, 100%, 100%, and 95.2%, respectively.
2: Results of Case Study 1 Comparison of ToxCast [AC.sub.50] values (in [micro]M) for nuclear-receptor- related assays between PFOA (including its ammonium salt) and selected "prototypical" compounds DEHP (including its metabolite MEHP
), phenobarbital, and rifampicin.
The effects of combined exposure to genistein and MEHP
on prepubertal Sertoli cells still need further investigation.
Urinary levels of MEOHP and MEHHP, which are the oxidized metabolites of DEHP, were higher than those of DEHP and MEHP
and were also the most commonly detected urinary metabolites (Table 1).
Our study suggested that the amount of melted DEHP and MEHP
would be even higher when infusion sets in S- line exposed to temperatures at 39-40C.
Interestingly, of the three metabolites of DEHP, MEHP
, MEHHP, and MEOHP , none showed a statistically trending association (in the multivariable adjusted model).
For example, a previous study reported that DEHP and mono-2-ethylhexyl phthalate (MEHP
) can pass through the placenta and shorten the gestational period of a developing fetus .
Previous research proved that some PAMs have greater solubility than corresponding PAEs, especially for monomethyl phthalate (MMP, 3721 mg/L), monobutyl phthalate (MBP, 409 mg/L), and mono-ethylhexyl-phthalate (MEHP
, 1.85 mg/L).
The administered doses of MEHP
, the chemical that results when animals metabolize the industrial phthalate DEHP, were much higher than any normal environmental exposure that people or animals would encounter, said Mary Hixon, assistant professor of pathology and laboratory medicine (research) in The Warren Alpert Medical School of Brown University and a study co-author.
Mono (2-etilhekzil) fitalat (MEHP
) DEHP'in ana metabolitidir ve DEHP'den daha toksiktir (4).