MEF2D

MEF2D

A gene on chromosome 1q12-q23 that encodes a transcriptional activator that binds specifically to the MEF2 element on various muscle-specific, growth factor- and stress-induced genes. MEF2D mediates cellular functions in skeletal and cardiac muscle development, in neuronal differentiation and survival, and in control of cell growth, survival and apoptosis via p38 MAPK signalling in muscle-specific and/or growth factor-related transcription.
Mentioned in ?
References in periodicals archive ?
The subtype is characterized by chromosomal rearrangements that involve the MEF2D gene and one of six partner genes, most often the gene BCL9.
Genomic analysis of more than 1,700 children, adolescents and adults with ALL identified 42 with MEF2D rearrangements.
Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects," Journal of Biological Chemistry, vol.