Activation of PPAR[gamma] could directly regulate miRNA-122 by binding to the PPRE in the promoter region and inhibit myocyte enhancer factor 2D (MEF2D) expression, an important biomarker of CM (Figure 3) .
Yu, "PPAR[gamma] suppresses the proliferation of cardiac myxoma cells through downregulation of MEF2D in a MIR-122-dependent manner," Biochemical and Biophysical Research Communications, vol.
We propose that CYD enhances adipogenesis and inhibits osteogenesis by regulating the expression of a number of key candidate genes, including FGF2, TGF[beta]2, Plat, EGR2, MEF2D, and IRS1.
Endochondral Actin Focal ossification cytoskeleton adhesion VEGFA FGF2 COL11A1 ADAMTS4 FGFR1 COL3A1 PLAT4 TMSB4X COL4A1 COL10A1 GNA13 COL4A2 TGFB2 PDGFA COL4A4 PTHrP FGF1 COL5A1 FGF2 ENAH COL5A2 C4ST1 MSN COL1A1 FGFR1 GSN LAMC2 PDGFRB PDGFRB THBS2 COL1 KRAS CAV2 MRAS ARHGAP5 SOS2 PTEN AKT3 PDGFA PDGFC PGF ITGA2 PDGFRB RAP1B MAPK8 TGF[beta] MAPK signaling signaling Adipogenesis SMURF1 MAPK8 FOXO1A MAPK8 NGFB TRIB3 SKP1 PDGFRB PCK2 NEDD9 RASA2 EGR2 ETS1 SOS2 DDIT3 KLF11 KRAS GADD45A ATF3 MRAS GADD45B FOSB NF1 HIF1A SKIL RAP1B IRS1 SMURF1 DUSP1 MEF2D ZFYVE16 DDIT3 FAS HSPB1 SPOCK IL1A FAS TGFB2 MAP313 ZAK AKT3 MAP3K8 GADD45A Table 2: Genes involved in osteogenesis-related pathways that are downregulated in CYD-treated hMSCs.
Davie, "Loss of MEF2D
expression inhibits differentiation and contributes to oncogenesis in rhabdomyosarcoma cells," Molecular Cancer, vol.
Furuya et al., "NF-kB, MEF2A, MEF2D
and HIF1-a involvement on insulin- and contraction-induced regulation of GLUT4 gene expression in soleus muscle," Molecular and Cellular Endocrinology, vol.
Zhang et al., "Indirubin-3-oxime effectively prevents 6OHDA-induced neurotoxicity in PC12 cells via activating MEF2D
through the inhibition of GSK3beta," Journal of Molecular Neuroscience, vol.
deficiency in neonatal cardiomyocytes triggers cell cycle re-entry and programmed cell death in vitro," The Journal of Biological Chemistry, vol.
She et al., "Activation of transcription factor MEF2D
by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects," Journal of Biological Chemistry, vol.
We found genes, whose gene products are either ribosomal proteins (RPL1, RPL6, EPL30, RPS17) or proteins involved in transcriptional or post-translational regulation (MEF2D
, NARS2; PATZ1, TTL), in RNA metabolism (PABPC1), or in protein biosynthesis (SLC6A17).
have demonstrated that MyoD collaborates with Mef2d
to trigger the expression of the target myogenin gene .