Meesmann corneal dystrophy

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Meesmann corneal dystrophy

An autosomal dominant condition OMIM:122100 characterised by fragility of the anterior corneal epithelium due to the presence of innumerable microcysts. Patients are typically asymptomatic until adulthood when the corneal microcysts rupture, causing erosions and symptoms including photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment.

Pathology
Disorganised and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.

Molecular pathology
Caused by defects of KRT3, which encodes cornea-specific keratin 3, and KRT12, which encodes cornea-specific keratin 12 (which together form a heterotetrameric complex).
References in periodicals archive ?
As it has done in previous editions, especially in the 2017 edition, the MECD will emphasize the different aspects of the Spanish education system, divided into these thematic areas:
In this edition of the Classroom there will be a stand in which the Reading Promotion Plan will be thoroughly known, promoted by the MECD in May 2017.