MDRD

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MDRD

A randomised trial with 2–4 years of planned followup that asked whether restriction of protein in the diet reduced the incidence of end-stage renal disease and death. While the early conclusion (1994) was that reduction was an insignificant, subsequent analysis (1999) concluded that the balance of evidence suggested a beneficial effect of protein restriction.

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Today, clinical laboratories customarily calculate eGFR using either the MDRD or CKD-EPI equation whenever a serum creatinine is obtained.

The authentication of kidney disease is no easy task

Abbreviations GFR --glomerular filtration rate cysC --cystatin C CKD --chronic kidney disease ESRD --end stage renal disease CV --cardiovascular DTPA --diethylenetriamine pentaacetate MDRD --Modicifaction of Diet in Renal Disease CKD-EPI --The Chronic Kidney Disease Epidemiology Collaboration [Cre.sub.equ] --formulas for calculating the GFR from serum concentrations of creatinine [CysC.sub.equ] --formulas for calculating the GFR from serum concentrations of cystatin C PENIA --particle enhanced nephelometric immunoassay PETIA --particle enhanced turbidimetric immunoassay PE --preeclamspia DM --diabetes mellitus DN --diabetic nephropathy CCIMT --intimo-medial complex of the common carotid artery Review article

Cystatin C--more than the marker of the glomerular filtration rate/Cistatin C--vise od markera jacine glomerulske filtracije

Reasons to use the MDRD or CKD-EPI study equation to estimate GFR (5):

Identifying Chronic Kidney Disease: An Overview of the Equations for Estimating Impaired Renal Function

Caption: FIGURE 1: Scatter plots of the isotopic glomerular filtration rate (GFR) versus 1/creatinine, creatinine clearance, 1/cystatin C, Cockcroft-Gault formula, MDRD equations with 4 and 6 variables, CKD-EPI-Cr, CKD-EPI-CysC, and CKD-EPI-Cr-CysC.

Evaluation of serum as a marker of early renal impairment in patients with liver cirrhosis

* MDRD estimates GFR based on age, race, sex, and serum creatinine.

Screening and monitoring HIV-positive people for CKD

Using the 4-parameter MDRD equation, we compared the eGFR calculated from creatinine values obtained by various field methods between 2006 and 2011.

Recent trends in performance and current state of creatinine assays

The two main formulas for the calculation of GFR are the Cockroft-Gault and MDRD (Modification of Diet in Renal Disease), although currently the most widely used is a modification of the simplified MDRD formula (sMDRD or simplified MDRD).

TNM-like classification: a new proposed method for heart failure staging

The MDRD study equation was developed in the USA using data from patients with CKD and there have been several versions of the equation.

Glomerular filtration rate (GFR) and estimation of the GFR (eGFR) in adults: the GFR is the best overall measure of renal function

Glomerular filtration rate was calculated using the Modification of Renal Diet (MDRD) equation.

Successful transplantation of HIV patients: The Louisiana experience

Estimated glomerular filtration rate (eGFR) was calculated by two formulas; Cockcroft-Gault (CG) and Modification of Diet in Renal Disease Study (MDRD) (12, 13).

Neutrophil gelatinase-associated lipocalin levels in right and left heart failure: an observational study/Sag ve sol kalp yetersizliginde notrofil jelatinaz-birlesik lipokalin seviyeleri: gozlemsel bir calisma

This equation is more accurate in determining kidney function than is the Modification of Diet in Renal Disease (MDRD) study equation, said Dr.