POLG

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POLG

A gene on chromosome 15q25 that encodes the catalytic subunit of mitochondrial DNA polymerase involved in replication of mitochondrial DNA.

Molecular pathology
POLG mutations cause progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS) and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE).
References in periodicals archive ?
Expression and purification procedures for recombinant mycobacterial antigens (ESAT-6, CFP-10, MDP1, Ag85A, Acr, HBHA, and HrpA [Acr2]) were described previously [36].
In our study, we observed a significant decrease in IgG levels against Acr and HrpA and in IgG avidity levels against MDP1 and Ag85A, during treatment (Supplemental Figure 1A-1B).
We found that CFP-10 and MDP1 IgG avidity before treatment showed a reverse association with serum CRP levels at entry (Figure 4(a)).
MDP1 is a mycobacterial histone-binding protein [43], which is reported to be strongly highly expressed during latent Mtb infection [44].
In this study, we found a significant decrease in IgG levels against Acr and HrpA and IgG avidity to MDP1 and Ag85A during treatment.
We found that IgG avidity to CFP-10 and MDP1 before treatment exhibited a negative association with serum CRP levels at entry.
Levels of serum IgG against 7 antigens (ESAT-6, CFP-10, MDP1, Ag85A, Acr, HBHA, and HrpA) before treatment (labeled as "before") and after treatment (labeled as "after") were analyzed by ELISA.
Caption: Figure 1: (a) Correlation between IgG levels and IgG avidity index against CFP-10 and MDP1 before treatment.
A description of the sources follows on 2:26--45 (English translation 2:115--37), with the prioritization of the sources (Quellenbewertung) on 2:46 (translation, 2:37--38), which indicates that the primary source for this edition (MDP1) is Mahler's personal annotated copy of the first edition (Weinberger).
Codigo Variables de la denticion MDI1 Diametro mesiodistal incisivo 1 MDI2 Diametro mesiodistal incisivo 2 MDC Diametro mesiodistal canino MDP1 Diametro mesiodistal premolar 1 MDP2 Diametro mesiodistal premolar 2 MDM1 Diametro mesiodistal molar 1 MDM2 Diametro mesiodistal molar 2 MDM3 Diametro mesiodistal molar 3 VLI1 Diametro vestibulolingual incisivo 1 VLI2 Diametro vestibulolingual incisivo 2 VLC Diametro vestibulolingual canino VLP1 Diametro vestibulolingual premolar 1 VLP2 Diametro vestibulolingual premolar 2 VLM1 Diametro vestibulolingual molar 1 VLM2 Diametro vestibulolingual molar 2 VLM3 Diametro vestibulolingual molar 3 (1) Variables disponibles por pieza para maxilar y mandibula, arcada derecha e izquierda.