Expression and purification procedures for recombinant mycobacterial antigens (ESAT-6, CFP-10, MDP1, Ag85A, Acr, HBHA, and HrpA [Acr2]) were described previously .
In our study, we observed a significant decrease in IgG levels against Acr and HrpA and in IgG avidity levels against MDP1 and Ag85A, during treatment (Supplemental Figure 1A-1B).
We found that CFP-10 and MDP1 IgG avidity before treatment showed a reverse association with serum CRP levels at entry (Figure 4(a)).
MDP1 is a mycobacterial histone-binding protein , which is reported to be strongly highly expressed during latent Mtb infection .
In this study, we found a significant decrease in IgG levels against Acr and HrpA and IgG avidity to MDP1 and Ag85A during treatment.
We found that IgG avidity to CFP-10 and MDP1 before treatment exhibited a negative association with serum CRP levels at entry.
Levels of serum IgG against 7 antigens (ESAT-6, CFP-10, MDP1, Ag85A, Acr, HBHA, and HrpA) before treatment (labeled as "before") and after treatment (labeled as "after") were analyzed by ELISA.
Caption: Figure 1: (a) Correlation between IgG levels and IgG avidity index against CFP-10 and MDP1 before treatment.
A description of the sources follows on 2:26--45 (English translation 2:115--37), with the prioritization of the sources (Quellenbewertung) on 2:46 (translation, 2:37--38), which indicates that the primary source for this edition (MDP1
) is Mahler's personal annotated copy of the first edition (Weinberger).
Codigo Variables de la denticion MDI1 Diametro mesiodistal incisivo 1 MDI2 Diametro mesiodistal incisivo 2 MDC Diametro mesiodistal canino MDP1
Diametro mesiodistal premolar 1 MDP2 Diametro mesiodistal premolar 2 MDM1 Diametro mesiodistal molar 1 MDM2 Diametro mesiodistal molar 2 MDM3 Diametro mesiodistal molar 3 VLI1 Diametro vestibulolingual incisivo 1 VLI2 Diametro vestibulolingual incisivo 2 VLC Diametro vestibulolingual canino VLP1 Diametro vestibulolingual premolar 1 VLP2 Diametro vestibulolingual premolar 2 VLM1 Diametro vestibulolingual molar 1 VLM2 Diametro vestibulolingual molar 2 VLM3 Diametro vestibulolingual molar 3 (1) Variables disponibles por pieza para maxilar y mandibula, arcada derecha e izquierda.