Also DNA damage response may play a positive role in repair damaged DNA of early embryos, and it may benefit from the functions of [gamma]H2AX below: firstly, [gamma]H2AX may work as it collects other signal or repair proteins to injured sites [16, 17, 23]; secondly, it localizes at kinetochores and calls together MDC1, MDC2
, and CDC20 for assembling an integrated mitotic checkpoint complexes ; finally, dynamic [gamma]H2AX in cell cycle reminds us of its specific role in the process of mitosis [18,35].
Patients with MDC2
(eye), MDC5 (cardiac), MDC6 (abdominal), MDC 12 (male genitourinary), MDC14 (female reproductive), MDC17 (oncology), MDC18 (infectious disease), and MDC19 (mental health) patients had lower odds of having an unplanned ED visit.
p-53-dependent benzene-induced decrease or increase Decrease Adcy6, ApoE, AQ1, B cell antigen receptor, Cam III, CCR9, E2F1, WT: decreased FATP4, Fscn1, GPCR (EB11), Ig kappa light chain, IgA, IgH, p53-KO: unchanged mur42, Pdk1, PPT-B, Prkm1, TP, TRBF1 Increase Adipose fatty acid binding protein, Adh-3, caspase-11, cyclin G1, WT: increased CYP7B1, EGFB-3, emp-1, FKBP23, c-fos, Hox-4.9, Int-1, Lfc, p53-KO: unchanged Krtl-12, mLimk1, MDC2
, Mtcp1, Nr2b1, p58 (PKI), Pcnt, PFK, Pkacb, PGII, PTG, beta- spectrin, SPI-3, SNK, TSC-2 C.