IL24

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IL24

A gene on chromosome 1q32 that encodes interleukin-24, a cytokine which may contribute to terminal cell differentiation. It has antiproliferative properties on melanoma cells. IL24 is also a popular, non-HUGO symbol for what is now designated IL17F, see there.

References in periodicals archive ?

Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).

Long non-coding RNA HOTAIR promotes UVB-induced apoptosis and inflammatory injury by up-regulation of PkR in keratinocytes

Other CB2 receptor-selective agonists MDA7, MDA19, JWH133, and LY2828360 were reported to prevent the development and suppress established paclitaxel-induced mechanical and cold allodynia [38, 42-46].

Xu et al., "MDA7: a novel selective agonist for CB2 receptors that prevents allodynia in rat neuropathic pain models," British Journal of Pharmacology, vol.

Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models

In results published online in the Neurobiology Of Aging, the compound MDA7 was found to interact with receptors in the brain that play a role in the neuro-degenerative processes in Alzheimer's.

New compound offers cure for Alzheimer's

In the study, the compound MDA7 induced beneficial immune responses that limited the development of Alzheimer's disease.