Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7
) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).
Other CB2 receptor-selective agonists MDA7, MDA19, JWH133, and LY2828360 were reported to prevent the development and suppress established paclitaxel-induced mechanical and cold allodynia [38, 42-46].
Xu et al., "MDA7: a novel selective agonist for CB2 receptors that prevents allodynia in rat neuropathic pain models," British Journal of Pharmacology, vol.
In results published online in the Neurobiology Of Aging, the compound MDA7
was found to interact with receptors in the brain that play a role in the neuro-degenerative processes in Alzheimer's.
In the study, the compound MDA7
induced beneficial immune responses that limited the development of Alzheimer's disease.