IFIH1

(redirected from MDA5)

IFIH1

A gene on chromosome 2q24.2 that encodes an RNA helicase which, through its ATP-dependent unwinding of RNA, may promote message degradation by specific RNases. It is thought to have roles in suppressing growth and involved in innate immune defence viruses.

Molecular pathology
Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19.
References in periodicals archive ?
Interestingly, MDA5 knockout mice develop demyelination of the central nervous system after viral infection.
The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): A retrospective study.
When physicians conducted a genetic analysis, it revealed she had a mutation in the IFIH1 gene that led her body to produce dysfunctional MDA5 proteins, which are vital to the immune system.
These findings helped the NIAID researchers conclude that properly functioning MDA5 is necessary to protect against human rhinoviruses (HRVs), the main causes of the common cold.
The analysis revealed that she had a mutation in the IFIH1 gene that caused her body to make dysfunctional MDA5 proteins in cells in her respiratory tract.
117) Zika virus infection of human fibroblasts increased the expression of TLR3, RIG-I, and MDA5 RNA.
TLR3 esta virtualmente presente en todos los peces y en particular, los teleosteos pueden responder a los dsRNA a traves de las vias de TLR3, RiG-1 y MDA5 (Ruyra et al.
However, MDA5 not only participates in antiviral responses, it also inhibits the growth of tumor cells, through type-I IFN (34,35).
The nature of these sensors has remained unknown until recently, when 2 putative RNA helicases, RIG-I and MDA5, were identified as sensors for viral dsRNA generated in the cytoplasm during viral infection (2-4).
The protein, also known as MDA5, recognizes RNA of picornaviruses and mediates immune activation within the body.