malondialdehyde-modified LDL

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malondialdehyde-modified LDL

A low-density lipoprotein, which is chemically modified in vivo, thought to reflect naturally occurring oxidation of LDL and serve as a surrogate marker for significant atherosclerosis; it is thus useful as a biochemical marker of coronary artery disease.
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According to MDA-LDL tertiles, 5 patients (42%) in the lowest tertile (T1), 4 (33%) in the middle tertile (T2), and 8 (67%) in the highest tertile (T3) had CAS (Figure 1(a)).
The present results showed by logistic regression analyses that MDA-LDL-related variables as well as MDA-LDL levels were independent predictors of CAS in asymptomatic type 2 diabetic patients.
Although increased serum levels of MDA-LDL are associated with the presence of CAD [8-10], several studies showed that MDA-LDL/LDL-C was more useful than MDA-LDL alone [11, 13].
In the current study, the AUC for the prediction of CAS was higher for MDA-LDL/HDL-C than for MDA-LDL alone in ROC analyses; similarly, the AUC was higher for (MDA-LDL/LDL-C)/HDL-C than for MDA-LDL/LDL-C.
This subcloning experiment resulted in seven stable subclones, which secreted approximately the 10-fold concentration of IgM antibodies binding to MDA-LDL compared to the mother clone and remained stable until freezing after six further passages.
Furthermore, as the human donor did not receive any kind of immunization against MDA-LDL, these results support the hypothesis that epitopes like MDA-LDL adducts are generated in vivo and may cause immune reactions leading to anti-MDA-LDL immunoglobulins.
In this respect, it should be noted that MDA-LDL IgM and copper oxidized LDL antibody titers decrease simultaneously after percutaneous coronary intervention and a subsequent increase of IgM antibodies persisted for one month and up to six months for IgG antibodies [27].
The specificity of these IgM antibodies secreted by the immortalized human x mouse hybridomas is not only supported by the fact that only MDA-LDL and [Cu.sup.++] oxidized-LDL can inhibit the immune reaction between antibodies and MDA-LDL bound to the solid phase but also by the finding that reducing substances such as antioxidants can prevent this immune reaction in a dose-dependent manner.
TG, MDA-LDL, and apo B concentrations were significantly higher in subjects with DM or hypertriglyceridemia than in control subjects [P <0.001 except for the difference in TG concentrations between diabetic patients and control subjects (P <0.01)].
LDL particle size was inversely correlated with TG and MDA-LDL concentrations and positively correlated with the HDL-C concentration.
RELATIONSHIPS AMONG TG CONCENTRATION, LDL SIZE, AND MDA-LDL
Mean values of MDA-LDL in each subgroup were calculated.