CCL7

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CCL7

A gene on chromosome 17q11.2-q12 that encodes monocyte chemotactic protein 3 (MCP-3), a secreted chemokine that attracts macrophages during inflammation and metastasis. MCP-3/CCL7 is a member of the C-C subfamily of chemokines, which have two adjacent cysteine residues, and is a ligand for CCR1, CCR2 and CCR3. It is an in vivo substrate of matrix metalloproteinase 2, an enzyme that degrades the extracellular matrix.
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Of note, CCL7/ MCP3 seemed to be the only cytokine strongly upregulated by TNF[alpha] independently of the day of culture and [Ca.sup.2+] concentration, whereas CCL22/MDC was the only cytokine for which overconfluency, and not [Ca.sup.2+] levels, contributed to its production.
Six signal factors, IL-1Ra, IL-7, IL-16, MCP3, TGF[beta]3, and VEGF, were detected only under 3D culture conditions.
According to the manufacturer's information, the minimum detectable dose of CX3CL1 for this test is typically less than 300pg/mL, and cross-reactivity was not observed with any of the cytokines tested including human angiogenin, BDNF, BLC, ENA-78, FGF-4, IL-1[alpha], IL-1[beta], IL-2, IL-3, IL-4, IL-5, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12 p70, IL-12 p40, IL-13, IL-15, IL-309, IP10, G-CSF, GM-CSF, IFN-[gamma], leptin, MCP-1, MCP-2, MCP3, MDC, MIP-1[alpha], MIP-1[beta], MIP-1[delta], PARC, PDGF, RANTES, SCF, TARC, TGF-[beta], TIMP-1, TIMP-2, TNF-[alpha], TNF-[beta], TPO, and VEGF (see Abbreviations).