CCL2

(redirected from MCP1)
Also found in: Acronyms.

CCL2

A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.
References in periodicals archive ?
IL6, MCP1 levels in (A-B) F1 and (C-D) F2 adult male offspring.
h] cells MCP1 pro Chemoattractant produced by injured tissue, or infection TNF[alpha] pro Macrophages [CD4.
To evaluate whether gene expression correlates with the corresponding proteins, we analyzed the secretion of IL1[beta], IL6, IL8, and MCP1 in supernatants of cultured precursors and adipocytes (Figure 2C).
NASDAQ:TEVA) covering CGEN-54, a Compugen-discovered novel splice variant of MCP1.
CGEN-54 is an antagonistic variant of MCP1 (Monocyte Chemoattractant Protein 1).
A number of attractive candidates - including this splice variant of MCP1 - were predicted that subsequently were manufactured and initially validated by Compugen," stated Alex Kotzer, President and Chief Executive Officer of Compugen.
Studies made on serum and cerebrospinal fluid (CSF) of 20 ALS patients show an increase of MCP1 and IL-8 levels, indicating a stimulation of proinflammatory cytokine cascade after microglia activation [124].
Gene symbol Gene name change 303649 MCP1 chemokine (C-C motif) ligand 2 2.
Nasdaq:CGEN) announced today the successful demonstration of functional activity for splice variants of c-Met receptor, MCP1 chemokine, and ANP hormone.
CGEN-54: An antagonistic variant of MCP1 (Monocyte Chemoattractant Protein 1)
Expression of IL6, CCL2/ MCP1, CXCL1/GRO1, and CXCL2/GRO2 is decreased in human fibroblast cells after treatment with 5 [micro]M arsenite for 0-24 hr (Yih et al.