CCL2

(redirected from MCP1)
Also found in: Acronyms.

CCL2

A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.
References in periodicals archive ?
Conclusion: The P-selectin and MCP1 values in the emergency department can differentiate sepsis patients according to the Q-SOFA criteria and showed 30-day mortality at a significant level.
Statins can partially refrain AT inflammation in obese mice [78], through the downregulation of mRNA MCP1 and IL6 expression [78] and also through inhibition of TLR4-induced expression of interferon-y in macrophages [78].
Curcumin antioxidant and anti-inflammatory effects seem to be linked to its hydroxyl and methoxy groups, whose functions end up giving a negative feedback in pro-inflammatory regulation of interleukins (IL-1,-2,-6,-8,-12) and cytokines (TNF-[alpha], MCP1) of enzymes and genes of pro-inflammatory cytokines.
Su administracion en monos macaco Rhesus despues de 10 minutos y 24 horas durante 14 dias post-exposicion con dosis letal del virus del Ebola, ha demostrado que ayuda a disminuir la respuesta pro-inflamatoria con disminucion serica de la interleuquina 6 y proteinas quimiostaticas de monocitos 1 (MCP1), lo cual le permite ser considerado una posible alternativa en el tratamiento contra este mortal virus (20).
* Inflammation and oxidative stress drives production of monocyte chemoattractant protein-1 (MCP1), recruiting monocytes and facilitating their penetration past the endothelium into the intima.
Jones, "Curcumin supplementation lowers TNF-[alpha], IL-6, IL-8, and MCP1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-[alpha], IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats," Antioxidants and Redox Signaling, vol.
A study by Willing et al [20] revealed that the stromal cells secrete a variety of cytokines and differentiation factors, including monocyte chemoattractant protein-1 (MCP1), osteoclast differentiation factor (ODF), and macrophage-colony stimulating factor (M-CSF).
Furthermore, EGCG attenuates TNF-[alpha]-induced production of monocyte chemotactic protein-1 (MCP1) and reduces Akt phosphorylation (Ahn et al.
The increase of TNF-[alpha] and, to some extent, MCP1 levels in our patients is in concordance with the results obtained in patients with parthenium dermatitis [17] and trichloroethylene-induced hypersensitivity [18] and might be explained by the activities of activated T cells [19].
Furthermore, activation of this pathway may contribute to the establishment and progression of atherosclerosis by inducing the proliferation of arterial smooth muscle cells and increased synthesis and secretion of IL-8 and monocyte chemotactic protein (MCP1).
showed that both high monocyte chemoattractant protein-1 (MCP1) expression and high macrophage infiltration in prostate cancer specimens correlate with a high prostate-specific antigen (PSA) recurrence rate and that AT1R blockade (ARB) inhibits MCP-1 expression through the PI3K/Akt pathway and blocks macrophage infiltration in castration-resistant prostate cancer [96].
Dimmer, "Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis," Journal of Cell Science, vol.