CCR2

(redirected from MCP-1 receptor)

CCR2

A gene on chromosome 3p21.31 that encodes a receptor for monocyte chemoattractant protein-1 (MCP-1), a chemokine that mediates monocyte chemotaxis through agonist-dependent calcium mobilisation and inhibition of adenylyl cyclase. MCP-1 plays a role in monocyte infiltration in inflammatory responses to rheumatoid arthritis and tumours.
References in periodicals archive ?
Lacking either IL-6 or MCP-1 receptor CCR2 will reduce the early onset of aortic dissections.
In contrast, a reduced dissection incidence was observed after angiotensin II infusion into mice lacking either IL-6 or the MCP-1 receptor CCR2.
A critical role of CCR2 (chemokine [C-C motif] receptor-2), a MCP-1 receptor on monocytes, has been also seen in hypertensives (32).