CCR2

(redirected from MCP-1 receptor)

CCR2

A gene on chromosome 3p21.31 that encodes a receptor for monocyte chemoattractant protein-1 (MCP-1), a chemokine that mediates monocyte chemotaxis through agonist-dependent calcium mobilisation and inhibition of adenylyl cyclase. MCP-1 plays a role in monocyte infiltration in inflammatory responses to rheumatoid arthritis and tumours.
References in periodicals archive ?
A critical role of CCR2 (chemokine [C-C motif] receptor-2), a MCP-1 receptor on monocytes, has been also seen in hypertensives (32).
However, because circulating neutrophils in the ALD patients lack MCP-1 receptors (Degre et al.