MCM8(redirected from MCM8 minichromosome maintenance deficient 8)
MCM8A gene on chromosome 20p12.3 that encodes one of the highly conserved minichromosome maintenance proteins (MCMs), which are involved in initiating eukaryotic genome replication. The hexamer (MCM 2-7) of MCM proteins is integral to the pre-replication complex, and may be involved in forming replication forks and recruiting other DNA replication related proteins; MCM8 co-immunoprecipitates with MCM4, -6 and -7, suggesting that it interacts with other MCM proteins and plays a role in DNA replication.
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