MCM7

MCM7

A gene on chromosome 7q21.3-q22.1 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA replication related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed by MCM2, MCM4, MCM6 and MCM7 regulates the complex’s helicase activity. Cyclin D1-dependent kinase (CDK4) associates with MCM7 and may regulate its binding to RB1/RB, the tumour suppressor protein. MCM7 interacts with ATR-ATRIP complex, MCMBP, RAD17 and TIPIN.
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qRT-PCR analysis confirmed that the mRNA levels of cyclin family members ( ccna1 , ccnb1 , ccnd1 , and cdk1 ), minichromosome maintenance proteins ( cdc45 , mcm2 , mcm3 , mcm4 , mcm5 , mcm6 , and mcm7 ), and proliferation cell nuclear antigen ( PCNA ) were significantly upregulated in ATF3-overexpressing CFs [Figure 3]a.
Recent breakthroughs identified the first elements of a mechanism of replication termination that involved ubiquitination of the mcm7 subunit of the cmg helicase.
Riccardi et al., "Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTENtargeting intron that cooperates with its host gene MCM7 in transformation," Science Signaling, vol.
Jin et al., "Upregulated expression of BCL2, MCM7, and CCNE1 indicate cisplatin-resistance in the set of two human bladder cancer cell lines: T24 cisplatin sensitive and T24R2 cisplatin resistant bladder cancer cell lines," Investigative and Clinical Urology, vol.
As can be expected, these genes can be assigned to different functional groups such as cell death regulators (CASP2, ING2, MDM4, NAIP), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, P0LR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), oxidative stress response (SPATS2L, GSTT2B, NQO1), DNA maintenance and processing (BAHCC1, FANCA, H1ST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), blood coagulation (FGA, MATR3, PROCR, P1K3CG), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2, P1K3CG, RALB, T1CAM2), cytoskeletal components (BCL7A, DYNC1LI2, SEPT10, SEPT11), transport functions (ABCC1, FXYD2, S100A6, SCNN1G, XP05), or others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
Samples were collected at 6 m (MCM1 and MCM7) and 9 m (MCM2 and MCM8) in Lake Fryxell and 13 m (MCM3 and MCM5) and 18 m (MCM4 and MCM6) in Lake WLB to capture the microbiology of distinct vertical physicochemical and biogeochemical layers within the trophogenic zone (region where adequate light exists to support phytoplankton photosynthesis) of the two lakes.
Malmstrom, "Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer," The American Journal of Pathology, vol.
Instead of hampering cell cycle, depletion of MCM7 causes activation of checkpoint signalling in human cancer cells, suggesting their roles in replication checkpoint signalling or activation of replication origins at the time of incomplete DNA replication [66, 67].
Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.
Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.
They found two, MCM3 and MCM7, that limited HIF-1a's activity, and were also part of the DNA replication machinery.
Genes such as MCM7 (4.78), DFFA (5.24), and PRPF38A (4.28) are engaged in gene regulation while E2F5 (6.60), RPS6KA3 (4.77), and YWHAZ (5.18) are associated with cell proliferation.