MCM6


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MCM6

A gene on chromosome 2q14-q21 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA replication related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed by MCM2, MCM4, MCM6 and MCM7 regulates the complex’s helicase activity.
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MCM4 and MCM6 had the highest DOC and DON concentrations (Table 1), which may explain why both estimated and observed richness in those samples were not lower than in other samples, taking confidence bounds into account (Fig.
Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.
Use of linkage disequilibrium and haplotype analysis of affected Finnish families revealed a defined DNA transition (-13910T/C) proximal to the LCT gene in intron 13 of the adjacent minichromosome maintenance type 6 gene (MCM6), which is associated with verified lactase nonpersistence and reduced bone mineral density predisposing for bone fractures (1, 2).
Minichromosome maintenance protein 2 (MCM2), which is in the same functional family as two other genes (MCM4 and MCM6) identified in the study of Chen et al.