7A), samples (MCMI, MCM2, MCM7, MCM8) collected from the same depth from Lake Fryxell (median oxygen, low salinity) clustered together regardless of season, followed by samples (MCM3 and MCM5; MCM4 and MCM6) from Lake WLB from different oxygen levels and salinities.
This novel OTU was also found in the MCM5 Lake WLB and MCM8 Lake Fryxell samples, where it was recovered with lower frequency (2.86% of all ciliates in MCM5, 0.60% of all ciliates in MCM8).
MCM5 is a prognostic marker of ovarian cancer and prostate cancer [104, 108].
It has been demonstrated that MCM5 is indispensable as a signal transducer and activator of transcription 1 (Stat 1) mediated transcriptional activation .
Cell growth-regulated expression of mammalian MCM5
and MCM6 genes mediated by the transcription factor E2F.
Scientists using high levels of a protein called Mcm5
have reported incredible success in detecting cancer cells.
DURHAM, SUNDERLAND & SOUTH TYNESIDE WINNER Arquer Diagnostics Ltd ARQUER are focusing their research efforts to apply MCM5
technology to diagnose a range of different cancers.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.g., CCNB1, PLK1) are coordinately induced and reach maximal expression levels between 8 and 24 hr (Figure 6B), consistent with the timing of the histologic changes observed in Figure 6A.
pombe) MCM5 100156_at mini chromosome maintenance deficient 5 CKSI 97468_at CDC28 protein kinase 1 ORC1 92458_at origin recognition complex, subunit 1-like (S.
The test focuses on the protein Mcm5
- a high level of which indicates presence of cancer cells.