MCM5


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MCM5

A gene on chromosome 22q13.1-q13.2 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA replication related proteins. The complex is required for the entry in S phase and for cell division. MCM5 is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may participate in cell cycle regulation.
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7A), samples (MCMI, MCM2, MCM7, MCM8) collected from the same depth from Lake Fryxell (median oxygen, low salinity) clustered together regardless of season, followed by samples (MCM3 and MCM5; MCM4 and MCM6) from Lake WLB from different oxygen levels and salinities.
This novel OTU was also found in the MCM5 Lake WLB and MCM8 Lake Fryxell samples, where it was recovered with lower frequency (2.86% of all ciliates in MCM5, 0.60% of all ciliates in MCM8).
MCM5 is a prognostic marker of ovarian cancer and prostate cancer [104, 108].
It has been demonstrated that MCM5 is indispensable as a signal transducer and activator of transcription 1 (Stat 1) mediated transcriptional activation [129].
Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.
Scientists using high levels of a protein called Mcm5 have reported incredible success in detecting cancer cells.
DURHAM, SUNDERLAND & SOUTH TYNESIDE WINNER Arquer Diagnostics Ltd ARQUER are focusing their research efforts to apply MCM5 technology to diagnose a range of different cancers.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.g., CCNB1, PLK1) are coordinately induced and reach maximal expression levels between 8 and 24 hr (Figure 6B), consistent with the timing of the histologic changes observed in Figure 6A.
pombe) MCM5 100156_at mini chromosome maintenance deficient 5 CKSI 97468_at CDC28 protein kinase 1 ORC1 92458_at origin recognition complex, subunit 1-like (S.
The test focuses on the protein Mcm5 - a high level of which indicates presence of cancer cells.