MCM3

MCM3

A gene on chromosome 6p12 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA-replication-related proteins. The complex is required for the entry in S phase and for cell division. MCM3 interacts directly with MCM5/CDC46; it is acetylated by MCM3AP, a chromatin-associated acetyltransferase, which inhibits the initiation of DNA replication and cell cycle progression.
References in periodicals archive ?
MCM3AP is an acetyltransferase that acetylases MCM3, and plays a role in DNA replication (Takei et al.
MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3.
Glycyrrhizin, silymarin, and ursodeoxycholic acid regulate a common hepatoprotective pathway in HepG2 cells
MCM1, MCM2, MCM3, and MCM4 (Table 3), leading us to conclude that these species may tolerate a range of salinities (Layboum-Parry and Pearce, 2007).
Table 1 Contextual data from our study Sample ID Contextual Data MCMI MCM2 MCM3 Collection Date (UTC) 11/22/07 11/22/07 11/30/07 Depth (Meters) 6 9 13 Lake (Name) Lake Fryxell Lake Fryxell Lake WLB Latitude (Decimal Degree) -77.
Ciliate diversity, community structure, and novel taxa in lakes of the McMurdo Dry Valleys, Antarctica
They found two, MCM3 and MCM7, that limited HIF-1a's activity, and were also part of the DNA replication machinery.
Low oxygen stops cell growth
We confirmed ER[alpha]-dependent responses to BPA, BPAF, and Zea by detecting endogenous gene expression of PR, GREBI (gene regulation by estrogen in breast cancer 1), MCM3 (minichromosome maintenance complex component 3), and SPUVE (also known as PRSS23; a member of the trypsin family of serine proteases) by real time-PCR (Figure 4).
GREB, MCM3, and SPINE have been reported to be ER-responsive genes (Henley et al.
Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor [alpha] and [beta] in vitro
As shown in Figure 3A, the expression of pS2, MYC, GREB1, SPUVE, and MCM3 was potentiated by [E.
However, some genes measured in this study, including GREB1 and MCM3, were not altered by treatment with MAA alone (Figure 3A).
The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-[alpha]-mediated signaling
Strain MCM3 grew only on mineral oil in addition to crude oil.
Petroleum utilizing Bacillus spp. from soil at Oil Springs, Texas
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.
Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth
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