MCM2


Also found in: Acronyms.

MCM2

A gene on chromosome 3q21 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA-replication-related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed by MCM2, MCM4, MCM6 and MCM7 regulates the complex’s helicase activity. MCM2 is phosphorylated, and thus is regulated, by protein kinases CDC2 and CDC7. It is also the retired HUGO symbol for MCM7.
References in periodicals archive ?
number Dilution Source OCT4 Abcam ab18976 1/250 Rabbit NANOG Abcam ab21624 1/100 Rabbit SSEA4 Abcam ab16287 1/100 Mouse TRA-1-81 Abcam ab16289 1/100 Mouse TRA-1-60 Abcam ab16288 1/100 Mouse SOX1 Abcam ab87775 1/200 Rabbit PAX6 DSHB 3B5 1/50 Mouse OTX2 Abcam ab21990 1/500 Rabbit LHX2 Santa Cruz sc-81311 1/200 Mouse Biotechnology SIX3 Rockland 600-401-A26 1/500 Rabbit MCM2 Abcam ab4461 1/400 Rabbit CHX10 Millipore ab9016 1/200 Sheep FIBRONECTIN Abcam ab2413 1/200 Rabbit ZO-1 Thermo Fisher 33-9100 1/400 Mouse BRN3 Santa Cruz sc-6026 1/200 Goat Biotechnology AP2 DSHB 3B5a 1/35 Mouse PROX1 Abcam ab101851 1/2000 Rabbit PKC-[alpha] Abcam ab32376 1/2000 Rabbit CRALBP Abcam ab15051 1/500 Mouse Rhodopsin Abcam ab3267 1/200 Mouse S opsin Gift from Dr.
Next, we compared the number of proliferating cells expressing the marker MCM2 in the glomerular layer, granular cell layer, and olfactory tract of control, as well as AD, PDD/DLB, or FTLD cases.
This PCR amplification was performed on replicate samples of MCM2, MCM5, and MCM8; results of next-generation sequencing are shown in Table 3.
In yeast, it has been found that depletion of MCM2 does not affect their growth rate but a 50% reduction of the dosage of MCM2 in yeast decreases the number of origins to be used per replication event.
Although some of these genes, such as MCM2 (25), NDRG1 (26), CBR1 (27), and EIF4A (28), have been identified as transcriptional markers of cancer, others, such as CALML5, have not been identified as having roles in SCCC or in other cancers.
Mcm2 is a member of the preinitiator complex essential for DNA replication.
mycoides (MCM2) were isolated from the soil samples.
Real-time PCR results showed that MCM2, RNA-SEH2A, and TOP2A were associated with colorectal carcinogenesis.
Changes in the expression of CDH2/4/6/17 were associated with increased expression of several important stem cell-related transcription factors including FOXM1, MCM2, WWTR1, and Sox9.
Ranking UniProtKB Protein name Site Score 1 Q08999 RBL2 S1035 0.4707 2 P28749 RBL1 S964 0.4672 3 P28749 RBL1 T369 0.4481 4 Q08999 RBL2 S672 0.4403 5 P28749 RBL1 S975 0.4389 6 Q08999 RBL2 T401 0.4313 7 Q9UQ35 SRRM2 T1413 0.3952 8 P49736 MCM2 S31 0.3736 9 Q9Y5N6 ORC6 T195 0.3717 10 P24928 POLR2A S1878 0.3663 11 Q15910 EZH2 T487 0.3653 12 Q9UQ35 SRRM2 T866 0.3553 13 O15446 CD3EAP S285 0.3505 14 P24928 POLR2A S1920 0.3495 15 P24928 POLR2A S1934 0.3492 16 Q02539 HIST1H1A S183 0.3488 17 P10276 RARA S77 0.3425 18 Q5TKA1 LIN9 T96 0.3412 19 Q9P1Z0 ZBTB4 T983 0.3347 20 P49736 MCM2 T59 0.3338 Figure 1: Construction of phosphorylation site-kinase network and extracting the pSKN profiles.
(8-10) During the past several years, literature has emerged regarding the value of minichromosome maintenance protein 2 (MCM2) and minichromosome maintenance protein 5 (MCM5) as immunoassays in urothelial carcinoma.
Stoeber et al., "Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology," Neuroscience Letters, vol.