MCM10

MCM10

A gene on chromosome 10p13 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. MCM10 juxtaposes MCM2-7 helicase and the DNA polymerase alpha/primase complex to initiate DNA replication, and it plays a role preventing DNA damage during replication.
References in periodicals archive ?
Our other findings considered to be a variant of unknown significance (VOUS) are OPTN, MCM10 and CCDC3 genes CNV duplication at 10p13, GRIP1 gene partial deletion at 12q14.3, CHRNA7 gene partial duplication at 15q13.3, miR128-1, ZRANB3, RHDM3 CNV deletions at 2q21.3 and MACROD2 gene partial deletion at 20p12.1.
Moreover, we identified a 230 kb duplication of 10p13 including OPTN, MCM10, CCDC3 genes in one patient.
Lee, "Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins," Proceedings of the National Academy of Sciences of the United States of America, vol.
Tye, "Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins," Genes and Development, vol.