MCM family

MCM family

Minichromosome maintenance family. A family of chromosome-interacting proteins, first identified in yeasts, that correspond to licensing factor, a complex of proteins responsible for a single controlled round of replication of chromosomal DNA in each mitotic cycle.
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Subsequent identification of proteins with a particular identical sequence termed "MCM box" [6] leads to the constitution of a protein family, the MCM family. The family consists of at least 6 homologues, MCM 2-7 [1], which is directly involved in eukaryotic DNA replication [7].
MCM paradox: abundance of eukaryotic replicative helicases and genomic integrity

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