MCM complex

MCM complex

Mini-chromosome maintenance complex. A group of 6 proteins (MCM2, -3, -4, -5, -6, and -7) that form a ring structure, which comprises the replicative helicase essential for the “once-per-cell cycle” DNA replication initiation and elongation in eukaryotic cells; it is required for the entry in S-phase and cell division. There are 6 active ATPase sites in the ring that contribute differentially to MCM complex’s helicase activity.
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This research focused on a ring-shaped enzyme called the minichromosome maintenance or MCM complex that plays a central role.
Enemark and his colleagues have produced the first atomic resolution image of the MCM complex bound to single-strand DNA and the molecules that fuel replication.
A cell prepares for the division process in part by loading MCM complexes onto its chromosomes.
They found that stem cells do indeed load MCM complexes much more quickly than mature, differentiated cells.