MCL1


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MCL1

A gene on chromosome 11q21 that encodes an anti-apoptotic protein of the Bcl-2 family.
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Key pipeline data that will be presented includes preclinical activity of the novel MCL1 inhibitor AZD5991 in multiple myeloma (Abstract #952), findings on the potential to overcome MCL1 resistance in multiple myeloma (Abstract #472), and data on the influence of myeloma patient-derived MCL1 point mutations in MCL1-inhibitor function (Abstract #951).
Immune response genes selected for the study (TLR2, NFKB1, IL2, IL16, TNF, IFNG, CXCR3, CCL1, CD81, CD84, RPS6KB2, STK17B, PRKCB1, MCL1, EEF1G, NFATC4, EEF1 and IER5) were amplified from cDNA of PBMCs (Fig.
The protein is elevated in a variety of cancers, and a number of MCL1 inhibitors are in the cancer drug development pipeline worldwide.
To further test this finding, we evaluated the gene expression levels of all four apoptosis signaling-related genes predicted to be targeted by miR-125b, namely BAK1, CASP2, MAP2K7, and MCL1. As predicted, all four genes showed decreased expression levels in the formaldehyde-exposed versus unexposed samples.
[21] Human genes: BCL2, B-cell CLL/lymphoma 2; MCL1, myeloid cell leukemia sequence 1 (BCL2-related).
et al., Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.
While a modified V1 or MCL1 can be obtained with this lead configuration, evidence shows that during wide-complex tachycardias, the QRS morphology in MCL1 differs considerably from that of a true V1, making MCL1 inadequate for distinguishing VT versus SVT (Drew & Scheinman, 1995).
Los miembros de la subfamilia Bol-2, tales como Bcl-XL, Al, Bcl-W y Mcl1 poseen actividad anti-apoptutica y estan caracterizados por poseer cuatro dominios BH homologos a Bcl-2.
The data presented demonstrate the synergistic induction of apoptosis of voruciclib when combined with venetoclax via the transient downregulation of MCL1 in multiple AML cell lines and patient samples.
The data show that INT-1B3 specifically targets pivotal oncogenes including MCL1, CCND1 and KRAS to induce cell death and apoptosis.
Mysliwski et al., "Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition," Leukemia, vol.
The collaboration focuses on complicated molecular targets, with some, such as Mcl1, thought, until recently, to be undruggable.