MCH is a 19-amino acid neuropeptide encoded by the Pmch gene and can bind to 2 G-protein-coupled receptors, the MCH receptor 1 (MCHR1
) and MCH receptor 2 (MCHR2).
These genes were: Amh, Amhr2, Crh, Crhbp, Crhr1, Crhr2, Emr1, Emr4, Fshb, Fshr, Gh, Ghitm, Ghr, Ghrh, Ghrhr, Ghsr, Gnrh1, Gnrhr, Gpha2, Gphb5, Lhb, Lhcgr, Lipe, Lipe, LOC676160, Mchr1
, Pgr, Pgrmc1, Pgrmc2, Pibf1, Pmch, Pome, Prlh, Prlhr, Pth, Pth1r, Pth2, Pth2r, Pthlh, Shbg, Thra, Thrap3, Thrb, Thrsp, Trh, Trhr, Trhr2, Trip10, Trip11, Trip12, Trip13, Trip4, Trip6, Tshb, and Tshr.
Accordingly, mice knocked-out for the gene coding for the protein Ankyrin Repeat Domain 26 (ANKRD26), which functions in protein-protein interactions, which show ciliary defects and mislocalization of the melanin concentrating hormone receptor 1 (MCHR1
) and of the somatostatin receptor 3 (SST3R) in the paraventricular nucleus of the hypothalamus, are also hyperphagic and obese .
Global Markets Direct's, 'Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1) - Pipeline Review, H1 2016', provides in depth analysis on Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1) targeted pipeline therapeutics.
The report provides comprehensive information on the Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1
) in murine models of depression.
A series of quinazoline derivatives (104-106) are to be considered as an antagonist for melanin concentrating hormone receptor 1 (MCHR1)  (see Scheme 71).
Kanna Reddy et al., "Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: part 2," Bioorganic and Medicinal Chemistry Letters, vol.
These physiological functions are mediated by melanin-concentrating hormone receptor 1 (MCHR1
) and melanin-concentrating hormone receptor 2 (MCHR2) in the G protein-coupled receptor family.
Several melanocyte autoantigens have been detected in vitiligo patients including tyrosinase, tyrosinase-related protein 1, tyrosinase-related protein 2, melanosomal matrix protein gp 100 (Pmel17), melanocyte transcription factor (SOX10), and melanin concentrating hormone receptor 1 (MCHR1
Examples of these upregulated genes include LALBA  (lactalbumin, alpha-), which encodes a principal milk protein that enables lactose production; CCKAR (cholecystokinin A receptor), which encodes a major physiological mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach; HCRTR2 [hypocretin (orexin) receptor 2], which encodes a protein involved in stimulation of food intake; MCHR1 (melanin-concentrating hormone receptor 1), which encodes a protein involved in neuronal regulation of food consumption; and DMP1 (dentin matrix acidic phosphoprotein 1), which encodes an extracellular matrix protein crucial for proper mineralization of bone and dentin (see Table 2 in the online Data Supplement).
 Human genes: LALBA, lactalbumin, alpha-; CCKAR, cholecystokinin A receptor; HCRTR2, hypocretin (orexin) receptor 2; MCHR1, melanin-concentrating hormone receptor 1; DMP1, dentin matrix acidic phosphoprotein 1; AES, amino terminal enhancer of split; CEACAM1, carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); SFTPB, surfactant protein B; FREM2, FRAS1 related extracellular matrix protein 2.