CASP10

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CASP10

A gene on chromosome 2q33-q34 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development. CASP10 is an initiator-type caspase which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains. It cleaves and activates caspase-3, -4, -6, -7, -8 and -9, is recruited to Fas- and TNFR-1 receptors in a FADD-dependent manner, and may participate in the granzyme B apoptotic pathways. It is expressed in most tissues. CASP10 is also a less preferred gene symbol for what is now designated PPIG, see there. 

Molecular pathology
Defects in CASP10 have been linked to gastric cancer, non-Hodgkin lymphoma and autoimmune lymphoproliferative syndrome type 2A.
References in periodicals archive ?
Similar to the dividend payout model, control variables ROA (Mch2 and 4), CF (Mch3 and 5) and FS (Mch1) are at a statistically significant level in all models in which they are present, regardless of the change option and additionally signs of parameter estimates standing by them are consistent with expectations derived from the maturity (Mch1), pecking order (Mch2 and 3) and free cash flow (Mch4 and 5) theories.
The frequencies of putative null alleles in those 3 loci as estimated with the method of Brookfield1 (Brookfield 1996) were as follows: Mch2, 0.289; Mch4, 0.322; and Mch7, 0.189.