MCF2

A gene on Xq27 that encodes an oncogenic protein, a guanine nucleotide exchange factor (GEF) which controls some of the Rho family of small GTPases, promoting the conversion of some from the GDP-bound to the GTP-bound form. The MCF2 protein product is cleaved into MCF2-transforming protein and DBL-transforming protein.

References in periodicals archive ?

MCF2 L, which codes for the Rho-specific guanine nucleotide exchange factor Dbs that catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1 has been shown to be associated with knee and hip OA.

Epidemiology and genetics of osteoarthritis

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