MC3R expression was found in murine and rat macrophages [39,40] and in RAW 264.7 cells  and expression of MC1R, MC3R, and MC5R
was detected in THP-1 cells [27,42].
These effects are caused by a-MSH interacting with its specific membrane receptors: MC1R, MC2R, MC3R, MC4R, and MC5R
. In fur animals, growth-related features are particularly important as body weight is associated with the quantity of harvested skin/fur, which directly translates into its value.
(2001) suggested that HFABP and the melanocortin-receptor 5 (MC5R
) may constitute positional candidate genes for QTL affecting IMF.
To date, scientists have identified five melanocortin receptors (named MC1R through MC5R
), all of which differ slightly from each other regarding chemical structure, binding affinity for certain peptides, and biological function.
Taylor, "Both MC5r
and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice," The Journal of Immunology, vol.