MC3R

MC3R

A gene on chromosome 20q13.2-q13.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase. MC3R is expressed in tissues other than the adrenal cortex and melanocytes.

Molecular pathology
MC3R mutations are associated with susceptibility to obesity.
References in periodicals archive ?
The findings were made possible by the team's development of a new transgenic animal model, where expression of the MC3R gene can be selectively "switched on" in different cell types.
5,6) Similar to MC4R polymorphisms, common variants in MC3R show significant frequency variation among different populations, accompanied by controversial effects on obesity phenotypes.
We analysed MC4R and MC3R for sequence variants that may contribute to the development of obesity in pupils from South Africa.
Human and animal studies support the role of MC4R in human obesity, (3,13) while MC3R variants have recently been implicated as pathogenic mutations that may cause dominantly inherited obesity.
5 mmHg) in coloured pupils further supports the dual role of MC3R in weight and blood pressure regulation.
No sequence variants were identified on MC4R, while two common sequence variants (T6K and V81I) were identified in the MC3R coding region.
Although the MC3R variants show a negative effect in blood pressure and weight gain among coloured pupils, the prevalence of metabolic syndrome among black and coloured pupils was not significantly different.
Our results support the role of MC3R variants in weight regulation, with larger effects in the coloured population, in whom T6K and V81I polymorphisms also exact different metabolic effects, supporting the dual role of MC3R in regulating body weight and blood pressure.
Essa classe de receptores tem seis isoformas que sao: MC1R, MC2R, MC3R, MC4R, MC5R e o MC6R, porem somente o MC2R e expresso na glandula adrenal (FLUCK; MILLER, 2008).
announced today that its researchers have discovered that activation of melanocortin receptors (MCR) subtypes MC1R and MC3R could be a novel strategy to control inflammatory disorders.
Preclinical investigations indicate that activation of certain MCR subtypes, primarily MC1R and MC3R, could be useful in treatment of localized and systemic inflammatory disorders.