MC3R

MC3R

A gene on chromosome 20q13.2-q13.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase. MC3R is expressed in tissues other than the adrenal cortex and melanocytes.

Molecular pathology
MC3R mutations are associated with susceptibility to obesity.
References in periodicals archive ?
Agonists and antagonists to the melanocortin receptors MC4R and MC3R are among the most powerful drugs for changing body weight in rodents, but application to humans has not been successful because of strong undesirable side effects.
Pharmacotherapy for Patients with Obesity
In the brain, the most abundant MCR subtypes are MC3R and MC4R [35,36].
Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases
Taheri, "Association of CTSZ rs34069356 and MC3R rs6127698 gene polymorphisms with pulmonary tuberculosis," The International Journal of Tuberculosis and Lung Disease, vol.
The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-[gamma] Release Assay-Positive Patients
[alpha]-MSH regulates food intake and energy homeostasis by acting on melanocortin-3 receptors (MC3R) and melanocortin-4 receptors (MC4R).
[alpha]-MSH Influences the Excitability of Feeding-Related Neurons in the Hypothalamus and Dorsal Vagal Complex of Rats
These effects are caused by a-MSH interacting with its specific membrane receptors: MC1R, MC2R, MC3R, MC4R, and MC5R.
Single Nucleotide Polymorphism of Melanocortin-4 Receptor Gene in American Mink (Neovison vison)
These peptides act on the melanocortin receptors (MCR), chiefly MC4R and MC3R, distributed throughout the central nervous system.
Obesity and arterial hypertension
Alpha-melanocyte-stimulating hormone ([alpha]-MSH) is a potent anorexigenic neuropeptide (5); leptin stimulates the production of [alpha]-MSH, which is an agonist for melanocortin-4 receptors (MC4R) and melanocortin-3 receptors (MC3R), and inhibits the production of AgRP (an antagonist for these receptors) in a coordinated manner to regulate the energy balance by inhibiting food intake and stimulating energy expenditure (6).
Alpha-Melanocyte-Stimulating Hormone and Agouti-Related Protein: Do They Play a Role in Appetite Regulation in Childhood Obesity?
aMSH modulates its downstream homeostatic signalling via their action at melanocortin receptors MC3R and MC4R, which are antagonized by AgRP [2].
Energy balance regulating neuropeptides are expressed through pregnancy and regulated by interleukin-6 deficiency in mouse placenta
The study focused on the melanocortin-3 receptor (MC3R), which normally responds to signals of nutrient intake.
Gene responsible for maintaining steady weight uncovered
(4) Recently, obesity-related mutations (A293T, I335S, X361S, I183, A70T and M134I) have been identified in the melanocortin-3 receptor gene (MC3R) - another energy-regulating melanocortin receptor.
Negative association of MC3R variants with weight and blood pressure in Cape Town pupils aged 11-16 years
Essa classe de receptores tem seis isoformas que sao: MC1R, MC2R, MC3R, MC4R, MC5R e o MC6R, porem somente o MC2R e expresso na glandula adrenal (FLUCK; MILLER, 2008).
Expression of genes related to the adrenocortical function in the neoplastic cachexia process/Expressao de genes relacionados a funcao adrenocortical no estado de caquexia neoplasica
Functional study showed that AgRp and Mc3r were significantly upregulated in the neuron specific Lpl knock-out mice [51].
Candidate Gene Identification of Feed Efficiency and Coat Color Traits in a C57BL/6J x Kunming F2 Mice Population Using Genome-Wide Association Study
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