MC2R


Also found in: Acronyms.

MC2R

A gene on chromosome 18p11.2 that encodes ACTH receptor, the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC2R cause glucocorticoid deficiency type 1.
References in periodicals archive ?
In an attempt to elucidate how antioxidants induce the production of glucocorticoids by the HPA axis, we analyzed the expression of adrenal MC2R. Prolonged treatment with NAC increases adrenal MC2R expression.
Although the increased expression of MC2R and StAR alone may explain the increase in glucocorticoids levels, other molecular alterations can also participate in the HPA axis hyperactivity noted after antioxidant treatment.
Caption: Figure 2: NAC induces an upregulation of MC2R and StAR expression in the zonafasciculata of the adrenal of Wistar rats.
* The report reviews Adrenocorticotropic Hormone Receptor (Adrenocorticotropin Receptor or Melanocortin Receptor 2 or MC2R or ACTHR) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Chiueh, "Centralized channel assignment and routing algorithms for multi-channel wireless mesh networks," ACM SIGMOBILE Mobile Computing and Communications Review (MC2R), vol.8, no.2, pp.
Genetic polymorphisms of MC2R gene associated with responsiveness to adrenocorticotropic hormone therapy in infantile spasms.
Este hormonio e reconhecido pelo seu receptor localizado na adrenal, o MC2R (IDELMAN; VERDETTI, 2000).
Os genes selecionados no presente trabalho (MC2R, 3[beta]HSD I, StAR e TSPO) participam do controle da cascata da esteroidogenese e sua analise fornece um indicativo do padrao de resposta funcional do cortex da glandula adrenal e o controle da mesma pelo hormonio adrenocorticotrofico.
Diante dos argumentos apresentados, a proxima etapa deste trabalho foi estudar a atividade do cortex adrenal por meio do estudo da expressao de genes MC2R, 3[beta]HSD I, StAR e TSPO em glandulas adrenais de animais-controle e portadores de tumor Walker-256 com caquexia avancada, sacrificados no decimo dia apos inoculacao tumoral.
A analise de densitometria das bandas dos produtos de RT-PCR (Figura 4A) demonstrou reducao significativa da expressao dos transcritos para MC2R no Grupo-tumor em relacao ao controle.
O estudo da glandula adrenal nesta fase revelou diminuicao na expressao de genes que codificam fatores importantes na esteroidogenese adrenal: MC2R, 3[beta]HSD I e TSPO, indicando falencia da glandula adrenal.
Expression, desensitization, and internalization of the ACTH receptor (MC2R).