MC1R


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MC1R

A gene on chromosome 16q24.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2, and are linked to cutaneous malignant melanoma type 5.
References in periodicals archive ?
Taunts like carrot-top and gingernut that come with having the MC1R gene are more familiar to some redheads than their own names.
When a-melanocyte-stimulating hormone (a-MSH) binds to MC1R, MC1R signaling is activated, eumelanin synthesis is induced, and dark colours are produced; otherwise, pheomelanin is generated alone and lighter colours are produced in the absence of MC1R signaling [6].
On the surface of melanocytes is a protein known as melanocortin 1 receptor, or MC1R.
Around 25% of UK adults have one version of the gene called MC1R which increases their risk of malignant melanoma.
The MC1R gene variant can boost the risk of skin cancer by the equivalent of 21 extra years of sun exposure, say scientists.
The researchers said even people with one copy of the crucial MC1R gene -- who may be fair-skinned but not have red hair -- have a higher risk.
Global Markets Direct's, 'Melanocyte-Stimulating Hormone Receptor (Melanocortin Receptor 1 or MC1-R or MC1R or MSHR) - Pipeline Review, H1 2016', provides in depth analysis on Melanocyte-Stimulating Hormone Receptor (Melanocortin Receptor 1 or MC1-R or MC1R or MSHR) targeted pipeline therapeutics.
This first-of-its-kind research, published in the journal Current Biology, discovered that individuals with one form of a gene called MC1R looked two years older than those with a different form.
Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis.
There are a number of recessive MC1R alleles, which have a high penetrance in individuals with red hair.