MC1R


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MC1R

A gene on chromosome 16q24.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2, and are linked to cutaneous malignant melanoma type 5.
References in periodicals archive ?
Investigation of TYR and MC1R polymorphisms in Korean chickens and the commercial chickens.
According to a report in the Telegraph, the gene known as MC1R suggests the Neanderthals had fair skin and even freckles like redheads.
On the other hand, the single nucleotide polymorphism (SNP) markers in MC1R gene were not sufficient for the discrimination of these Korean native chicken lines (data has not shown).
In addition, a set of genes including GHR, MC1R, FABP3, CLPN3, SPERT, HTR2A5, ABCE1, BMP4 and PTGER2 were possibly subject to selective sweeps (Flori et al.
MC1R corresponds to an extension locus (E; Little, 1957), and three alleles (E/[E.
In Korea, a breed discrimination marker based on the coat color related MC1R (melanocortin 1 receptor) gene between Hanwoo and Holstein was developed (Kim et al.
In addition, the expression of 7 cytokines genes (IL-22, VEGFA, IL26, CXCL14, BMPER, IL-17D, and CCL20) and 16 receptor genes (IL-22RA1, CXCR3, IL-17RC, IL-1RAPL2, IFITM5, NRG2, TNFRSF14, LEPREL2, IL-11RA, LTBP2, ILDR1, IL-17RD, MC1R, IL-22RA2, LEPREL1, and LILRA5) were significantly downregulated by 3.
The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma.
In order to have red hair, a person must possess the MC1R gene, which is recessive and only occurs in about 2 percent of the world's population, says the National Institutes of Health.